{"product_id":"antibiotic-medium-no-1-official-standardized-assay-medium","title":"Antibiotic Medium No. 1","description":"\u003ch3 data-start=\"176\" data-end=\"205\"\u003eAntibiotic Medium No. 1\u003c\/h3\u003e\n\u003cp data-start=\"206\" data-end=\"271\"\u003eOfficial Standardized Assay Medium for Antibiotic Potency Testing\u003c\/p\u003e\n\u003cp data-start=\"273\" data-end=\"302\"\u003e\u003cstrong data-start=\"273\" data-end=\"292\"\u003eCatalog Number:\u003c\/strong\u003e AS-1108\u003c\/p\u003e\n\u003ch4 data-start=\"304\" data-end=\"319\"\u003eOverview\u003c\/h4\u003e\n\u003cp data-start=\"320\" data-end=\"766\"\u003eAntibiotic Medium No. 1 is the globally recognised \u003cstrong data-start=\"371\" data-end=\"396\"\u003estandard solid medium\u003c\/strong\u003e used for antibiotic potency determination by \u003cstrong data-start=\"442\" data-end=\"472\"\u003ecylinder-plate (cup-plate)\u003c\/strong\u003e and \u003cstrong data-start=\"477\" data-end=\"494\"\u003eturbidimetric\u003c\/strong\u003e microbiological assay methods. Originally developed by \u003cstrong data-start=\"550\" data-end=\"578\"\u003eGrove and Randall (1955)\u003c\/strong\u003e, it is specified as \u003cstrong data-start=\"599\" data-end=\"613\"\u003e“Medium A”\u003c\/strong\u003e in \u003cstrong data-start=\"617\" data-end=\"641\"\u003eFDA (21 CFR 436.102)\u003c\/strong\u003e, \u003cstrong data-start=\"643\" data-end=\"655\"\u003eUSP \u0026lt;81\u0026gt;\u003c\/strong\u003e, \u003cstrong data-start=\"657\" data-end=\"689\"\u003eEuropean Pharmacopoeia 2.7.2\u003c\/strong\u003e, \u003cstrong data-start=\"691\" data-end=\"725\"\u003eJapanese Pharmacopoeia (JP 17)\u003c\/strong\u003e, \u003cstrong data-start=\"727\" data-end=\"734\"\u003eWHO\u003c\/strong\u003e, and \u003cstrong data-start=\"740\" data-end=\"755\"\u003eISO 20776-2\u003c\/strong\u003e standards.\u003c\/p\u003e\n\u003cp data-start=\"768\" data-end=\"1033\"\u003eThe formulation provides optimal growth conditions for commonly used test organisms, ensuring \u003cstrong data-start=\"862\" data-end=\"927\"\u003esharp, well-defined, and highly reproducible inhibition zones\u003c\/strong\u003e, which are essential for accurate antibiotic potency assessment in regulated pharmaceutical laboratories.\u003c\/p\u003e\n\u003ch4 data-start=\"1035\" data-end=\"1065\"\u003eKey Features \u0026amp; Benefits\u003c\/h4\u003e\n\u003cp data-start=\"1066\" data-end=\"1132\"\u003eGlobally harmonised formulation (USP \/ EP \/ BP \/ JP \/ WHO \/ ISO)\u003c\/p\u003e\n\u003cp data-start=\"1134\" data-end=\"1184\"\u003eProduces sharp and reproducible inhibition zones\u003c\/p\u003e\n\u003cp data-start=\"1186\" data-end=\"1239\"\u003eLow inter-laboratory and batch-to-batch variability\u003c\/p\u003e\n\u003cp data-start=\"1241\" data-end=\"1303\"\u003eRecognised reference medium for regulatory antibiotic assays\u003c\/p\u003e\n\u003cp data-start=\"1305\" data-end=\"1365\"\u003eSuitable for both agar-diffusion and turbidimetric methods\u003c\/p\u003e\n\u003ch4 data-start=\"1367\" data-end=\"1394\"\u003eTypical Applications\u003c\/h4\u003e\n\u003cp data-start=\"1396\" data-end=\"1560\"\u003e\u003cstrong data-start=\"1396\" data-end=\"1430\"\u003ePharmaceutical Quality Control\u003c\/strong\u003e\u003cbr data-start=\"1430\" data-end=\"1433\"\u003eMicrobiological potency assay of antibiotics including:\u003cbr data-start=\"1488\" data-end=\"1491\"\u003epenicillins, tetracyclines, aminoglycosides, macrolides, and others\u003c\/p\u003e\n\u003cp data-start=\"1562\" data-end=\"1607\"\u003eRoutine batch release and stability testing\u003c\/p\u003e\n\u003cp data-start=\"1609\" data-end=\"1702\"\u003e\u003cstrong data-start=\"1609\" data-end=\"1651\"\u003eCylinder-Plate \u0026amp; Agar-Diffusion Assays\u003c\/strong\u003e\u003cbr data-start=\"1651\" data-end=\"1654\"\u003eStandard medium for cup-plate diffusion assays\u003c\/p\u003e\n\u003cp data-start=\"1704\" data-end=\"1763\"\u003eUsed as seed agar or base agar depending on method design\u003c\/p\u003e\n\u003cp data-start=\"1765\" data-end=\"1841\"\u003e\u003cstrong data-start=\"1765\" data-end=\"1789\"\u003eTurbidimetric Assays\u003c\/strong\u003e\u003cbr data-start=\"1789\" data-end=\"1792\"\u003eSeed medium for turbidimetric antibiotic assays\u003c\/p\u003e\n\u003cp data-start=\"1843\" data-end=\"1898\"\u003eGrowth response measurement for potency determination\u003c\/p\u003e\n\u003ch4 data-start=\"1900\" data-end=\"1930\"\u003ePrinciple of the Medium\u003c\/h4\u003e\n\u003cp data-start=\"1931\" data-end=\"2247\"\u003eAntibiotic Medium No. 1 provides a balanced nutrient base that supports uniform growth of sensitive indicator organisms. Antibiotics diffuse evenly through the agar, producing inhibition zones whose diameter is directly proportional to antibiotic concentration, enabling precise and reproducible potency calculation.\u003c\/p\u003e\n\u003ch4 data-start=\"2249\" data-end=\"2287\"\u003eTypical Composition (per litre)\u003c\/h4\u003e\n\u003cp data-start=\"2288\" data-end=\"2310\"\u003eBeef Extract – 1.5 g\u003c\/p\u003e\n\u003cp data-start=\"2312\" data-end=\"2335\"\u003eYeast Extract – 3.0 g\u003c\/p\u003e\n\u003cp data-start=\"2337\" data-end=\"2371\"\u003ePeptone (meat or casein) – 6.0 g\u003c\/p\u003e\n\u003cp data-start=\"2373\" data-end=\"2392\"\u003eD-Glucose – 1.0 g\u003c\/p\u003e\n\u003cp data-start=\"2394\" data-end=\"2409\"\u003eAgar – 15.0 g\u003c\/p\u003e\n\u003cp data-start=\"2411\" data-end=\"2467\"\u003eFinal pH: \u003cstrong data-start=\"2421\" data-end=\"2465\"\u003e6.6 ± 0.1 at 25 °C (after sterilisation)\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch4 data-start=\"2469\" data-end=\"2487\"\u003ePreparation\u003c\/h4\u003e\n\u003cp data-start=\"2488\" data-end=\"2547\"\u003eSuspend 26.5 g of dehydrated medium in 1 L purified water\u003c\/p\u003e\n\u003cp data-start=\"2549\" data-end=\"2626\"\u003eHeat with frequent agitation and boil for 1–2 minutes until fully dissolved\u003c\/p\u003e\n\u003cp data-start=\"2628\" data-end=\"2650\"\u003eDispense as required\u003c\/p\u003e\n\u003cp data-start=\"2652\" data-end=\"2703\"\u003eSterilise by autoclaving at 121 °C for 15 minutes\u003c\/p\u003e\n\u003cp data-start=\"2705\" data-end=\"2735\"\u003eCool to 45–50 °C for pouring\u003c\/p\u003e\n\u003cp data-start=\"2737\" data-end=\"2830\"\u003eTypical layer thickness:\u003cbr data-start=\"2761\" data-end=\"2764\"\u003e1–2 mm base layer\u003cbr data-start=\"2781\" data-end=\"2784\"\u003e3–4 mm seeded layer containing test organism\u003c\/p\u003e\n\u003ch4 data-start=\"2832\" data-end=\"2858\"\u003eStorage \u0026amp; Stability\u003c\/h4\u003e\n\u003cp data-start=\"2859\" data-end=\"2918\"\u003eDehydrated medium: Store below 30 °C in a cool, dry place\u003c\/p\u003e\n\u003cp data-start=\"2920\" data-end=\"2992\"\u003ePrepared plates: Store at 2–8 °C, protected from light and desiccation\u003c\/p\u003e\n\u003cp data-start=\"2994\" data-end=\"3025\"\u003eRecommended use within 7 days\u003c\/p\u003e\n\u003ch4 data-start=\"3027\" data-end=\"3057\"\u003eStandard Test Organisms\u003c\/h4\u003e\n\u003cp data-start=\"3058\" data-end=\"3106\"\u003e\u003cem data-start=\"3058\" data-end=\"3081\"\u003eStaphylococcus aureus\u003c\/em\u003e ATCC 6538P \/ NCTC 7447\u003c\/p\u003e\n\u003cp data-start=\"3108\" data-end=\"3139\"\u003e\u003cem data-start=\"3108\" data-end=\"3127\"\u003eBacillus subtilis\u003c\/em\u003e ATCC 6633\u003c\/p\u003e\n\u003cp data-start=\"3141\" data-end=\"3173\"\u003e\u003cem data-start=\"3141\" data-end=\"3161\"\u003eKocuria rhizophila\u003c\/em\u003e ATCC 9341\u003c\/p\u003e\n\u003cp data-start=\"3175\" data-end=\"3214\"\u003e\u003cem data-start=\"3175\" data-end=\"3202\"\u003eBordetella bronchiseptica\u003c\/em\u003e ATCC 4617\u003c\/p\u003e\n\u003ch4 data-start=\"3216\" data-end=\"3235\"\u003eIntended Use\u003c\/h4\u003e\n\u003cp data-start=\"3236\" data-end=\"3360\"\u003eFor laboratory and pharmaceutical quality-control use only.\u003cbr data-start=\"3295\" data-end=\"3298\"\u003eNot for clinical diagnostic, food, or veterinary applications.\u003c\/p\u003e\n\u003ch4 data-start=\"3362\" data-end=\"3389\"\u003eQuality \u0026amp; Compliance\u003c\/h4\u003e\n\u003cp data-start=\"3390\" data-end=\"3456\"\u003eLegally recognised standard medium for antibiotic potency assays\u003c\/p\u003e\n\u003cp data-start=\"3458\" data-end=\"3531\"\u003eComplies with USP \u0026lt;81\u0026gt;, EP 2.7.2, JP 17, WHO, FDA, and ISO requirements\u003c\/p\u003e\n\u003cp data-start=\"3533\" data-end=\"3597\"\u003eManufactured under controlled conditions for batch consistency\u003c\/p\u003e\n\u003cp data-start=\"3599\" data-end=\"3641\"\u003eCOA, SDS, and TDS available upon request\u003c\/p\u003e\n\u003ch4 data-start=\"3643\" data-end=\"3677\"\u003eCustoms \u0026amp; Trade Information\u003c\/h4\u003e\n\u003cp data-start=\"3678\" data-end=\"3785\"\u003eHS \/ AHECC Code: \u003cstrong data-start=\"3695\" data-end=\"3709\"\u003e3821.00.00\u003c\/strong\u003e\u003cbr data-start=\"3709\" data-end=\"3712\"\u003ePrepared culture media for development or maintenance of microorganisms\u003c\/p\u003e","brand":"Ausamics Life Science","offers":[{"title":"100G","offer_id":48051958513919,"sku":"AS-1108-DH-LS-100G","price":45.0,"currency_code":"AUD","in_stock":true},{"title":"500G","offer_id":48051958546687,"sku":"AS-1108-DH-LS-500G","price":125.0,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0771\/1087\/0271\/files\/culturemedia_image_f7b8161f-9f07-49aa-bb2c-24428fa1391f.jpg?v=1771063036","url":"https:\/\/ausamics.com.au\/products\/antibiotic-medium-no-1-official-standardized-assay-medium","provider":"AuSaMicS","version":"1.0","type":"link"}