Mannitol Powder is a high-purity polyol (sugar alcohol) widely used as a food-grade sweetener, pharmaceutical excipient, and functional ingredient across food, nutraceutical, cosmetic, and industrial applications. It is supplied as a white crystalline powder and valued for its low hygroscopicity, chemical stability, pleasant cooling sensation, and mild sweetness, making it particularly suitable for moisture-sensitive formulations.
AuSaMicS Mannitol Powder (ASC-8018) is manufactured under stringent quality controls to deliver consistent purity, particle quality, and performance across both small-scale artisan formulation and large-scale industrial production. Its versatility across multiple regulated sectors — food (E421), pharmaceutical excipient, nutraceutical, and cosmetic — makes it one of the most flexible polyols available.
Key Features & Benefits
High-purity, food-grade quality (E421)
Low hygroscopicity — improved product shelf life
Mild sweetness with a clean, cool taste
Pleasant cooling sensation in oral applications
Low glycaemic index — suitable for diabetic-friendly formulations
Non-cariogenic — does not contribute to dental decay
Heat-stable for cooking and baking applications
Excellent compatibility with actives and excipients
Suitable for direct compression in tablet manufacture
Multiple pack sizes for artisan to industrial scale
Chemical & Physical Properties
Chemical Name
D-Mannitol (D-(-)-Mannitol)
Synonyms
Manna Sugar, Mannite, D-Mannite, E421, Osmitrol, Mannidex, Resectisol
CAS Number
69-65-8
Molecular Formula
C₆H₁₄O₆
Molecular Weight
182.17 g/mol
E Number
E421 (food additive — bulk sweetener / humectant)
Appearance
White crystalline powder
Odour
Odourless
Taste
Mild sweetness (~50–60% of sucrose); cooling sensation
Solubility in Water
~182 g/L at 25°C; ~670 g/L at 90°C
Solubility in Ethanol
Slightly soluble
Melting Point
165–169°C
Optical Rotation [α]D²⁰
+23° to +24° (c = 10, in water)
Hygroscopicity
Very low — stable under ambient humidity
Caloric Value
~1.6 kcal/g (EU); ~1.6–2.4 kcal/g (US FDA)
Glycaemic Index
≤2 (negligible)
Catalogue Number
ASC-8018
Grade
Food Grade / Pharmaceutical Excipient Grade
Biochemistry & Mode of Action
Mannitol is a naturally occurring C₆ sugar alcohol (polyol), the reduced form of mannose. Unlike sucrose and glucose, mannitol is not phosphorylated by hexokinase and is poorly absorbed in the small intestine, resulting in a very low glycaemic response. In the colon, it is partially fermented by microflora. Its low water activity and non-hygroscopic crystalline structure arise from strong intermolecular hydrogen bonding in the solid state, which makes it an outstanding excipient for moisture-sensitive compounds. The endothermic heat of dissolution (~120 J/g) produces the characteristic cooling sensation on the tongue. Mannitol does not undergo Maillard reactions with amino acids under standard conditions, providing colour and flavour stability in heat-processed food products.
Ingredients & Composition
Component
Purity / Content
Function
Mechanism / Notes
D-Mannitol
≥98.0% (food grade); ≥99.0% (pharma grade)
Primary active — sweetener, bulking agent, excipient
Very low hygroscopicity — ideal for dry and moisture-sensitive formulations
Low GI — suitable for diabetic-friendly and low-sugar products
Non-cariogenic — does not feed oral bacteria
Pleasant cooling taste — excellent mouthfeel in oral dosage forms
No Maillard browning — colour-stable in heat-processed products
Suitable for direct compression in pharma tablet manufacture
Approved in food (E421), pharma (USP/EP/BP), and cosmetic sectors
Chemically inert — compatible with most actives and excipients
⚠ Considerations
Lower sweetness (~50–60% of sucrose) — may need blending
Laxative effect possible at high intake levels (>20 g/day)
Lower water solubility than sorbitol — may require warm water
Higher cost than sorbitol or dextrose per unit weight
EU labelling: products containing mannitol must carry "excessive consumption may have laxative effects" warning above 10% content
Not suitable as sole humectant — lacks moisture retention of sorbitol
Preparation & Dissolution Guide
Weigh the required quantity of mannitol powder using a calibrated balance
For aqueous solutions: add powder to purified or deionised water at room temperature or slightly warmed (40–60°C) and stir until fully dissolved
For tablet/capsule formulations: blend mannitol directly with active ingredients for direct compression; screen if required for uniform particle size
For confectionery: incorporate into recipe at the appropriate processing stage; mannitol is heat-stable up to its melting point (~165°C)
For oral care products: incorporate into the aqueous phase of the formulation with mixing
Adjust final concentration or blend ratio to achieve desired sweetness, texture, or bulking effect
Usage Considerations
Sweetness: Approximately 50–60% of sucrose. Can be blended with higher-intensity sweeteners (stevia, sucralose) to achieve target sweetness while maintaining mannitol's functional benefits.
EU Labelling Requirement: Food products containing more than 10% added polyols must carry the statement: "excessive consumption may produce laxative effects."
Pharmaceutical Use: Complies with USP, EP, BP, and JP monographs for Mannitol (excipient grade). Suitable for parenteral, oral solid dosage, and lyophilisation applications at appropriate specification levels.
Storage & Stability
🌡 Store at 15–25°C in a tightly sealed container. Protect from moisture and contamination. Due to its low hygroscopicity, mannitol remains stable and free-flowing under ambient conditions. Shelf life ≥3 years under recommended storage. Do not store near strong oxidising agents or reactive chemicals.
Intended Use: Food-grade product suitable for food, beverage, cosmetic, nutraceutical, and industrial formulation use. Not intended for therapeutic, diagnostic, or medical administration unless supplied under appropriate pharmaceutical-grade specification and documentation. Buyers are responsible for ensuring compliance with applicable food and formulation regulations in their jurisdiction, including the FSANZ Food Standards Code, EU Regulation (EC) 1333/2008, and applicable pharmacopoeial standards. AuSaMicS Pty Ltd | 31 Longview CT, Thomastown VIC 3074 | ABN: 56 676 640 467 | www.ausamics.com.au | support@ausamics.com | +61 412 520 598.
Technical Data Sheet — Mannitol Powder (ASC-8018)
1. Product Identification
Product Name
Mannitol Powder
Catalogue Number
ASC-8018
IUPAC Name
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
CAS Number
69-65-8
Molecular Formula
C₆H₁₄O₆
Molecular Weight
182.17 g/mol
E Number
E421
Grade
Food Grade / Pharmaceutical Excipient Compatible
Supplier
AuSaMicS Pty Ltd, Thomastown VIC 3074, Australia
2. Mode of Action & Functional Properties
Mannitol is a six-carbon polyol produced by reduction of the carbonyl group of mannose. In its crystalline β-polymorph form (the most common commercial form), mannitol exhibits very low hygroscopicity due to strong intermolecular hydrogen bonding in the crystal lattice, which minimises water adsorption even at elevated relative humidity. Its negative heat of solution (~120 J/g endothermic) produces the characteristic pleasant cooling sensation. As a non-reducing sugar alcohol, mannitol does not participate in Maillard reactions and is chemically inert toward most pharmaceutical actives, making it an ideal inert filler and diluent. Its negligible glycaemic response results from poor intestinal absorption and absence of insulin-stimulating activity.
3. Physical & Chemical Properties
Appearance
White crystalline powder
Purity (food grade)
≥98.0%
Purity (pharma-compatible)
≥99.0%
Melting Point
165–169°C
Solubility in Water (25°C)
~182 g/L
Solubility in Water (90°C)
~670 g/L
Optical Rotation [α]D²⁰
+23° to +24° (10% w/v aqueous)
pH (10% aqueous solution)
5.0–8.0 (neutral)
Loss on Drying
≤0.3%
Residue on Ignition
≤0.1%
Hygroscopicity
Very low (<0.3% moisture uptake at 60% RH)
Bulk Density
~400–600 g/L (varies with particle size grade)
Heat of Solution
~−120 J/g (endothermic — cooling sensation)
Reducing Sugars
≤0.1% (non-reducing)
4. Quality Control Specifications
Test Parameter
Method
Specification
Notes
Appearance
Visual
White crystalline powder, free-flowing
—
Assay (D-Mannitol)
GC or HPLC
≥98.0% (food); ≥99.0% (pharma)
Dry basis
Loss on Drying (105°C, 3h)
Gravimetric
≤0.3%
USP/EP/BP compliant specification
Residue on Ignition
Gravimetric (600°C)
≤0.1%
—
pH (10% aqueous solution)
Potentiometry
5.0–8.0
Neutral to slightly acidic
Optical Rotation [α]D²⁰
Polarimetry
+23.0° to +24.0°
10% w/v aqueous; confirms D-isomer
Reducing Sugars
Fehling / HPLC
≤0.1%
Non-reducing — confirms no glucose/fructose contamination
Heavy Metals (as Pb)
ICP-MS
≤10 ppm
—
Arsenic (as As)
ICP-MS
≤1 ppm
—
Chloride
Titration
≤50 ppm
—
Sulphate
Gravimetric/turbidimetric
≤100 ppm
—
Microbial Count (TPC)
Plate count
≤1000 CFU/g
Food grade specification; ≤100 CFU/g for pharma grade
E. coli
MPN / membrane filtration
Absent / 10 g
≤10 CFU per inoculum
Salmonella spp.
ISO 6579
Absent / 25 g
—
5. Typical Formulation Guidance
Application
Typical Inclusion Level
Function
Notes
Direct compression tablets
20–80% w/w
Filler / diluent
Excellent compressibility; pleasant taste for chewable tablets
Lyophilisation (freeze-drying)
1–10% w/v
Cryoprotectant / bulking agent
Forms elegant cake structure; widely used in biopharmaceuticals
Sugar-free confectionery
20–60% w/w
Bulk sweetener / anti-caking
Blend with high-intensity sweetener to compensate lower sweetness
Chewing gum
10–30% w/w
Cooling agent / sweetener
Provides freshness sensation
Toothpaste / oral care
5–30% w/w
Humectant / sweetener
Non-cariogenic; cooling effect
Powdered beverage mixes
5–20% w/w
Bulking / anti-caking agent
Low hygroscopicity prevents caking
6. Storage & Stability
Recommended storage: 15–25°C, tightly sealed, protect from moisture. Shelf life: ≥3 years from manufacture date under recommended conditions. Stability notes: Mannitol is chemically stable, non-hygroscopic under ambient conditions, and does not undergo significant degradation during standard food-processing or pharmaceutical manufacturing operations. Stable to autoclaving (121°C, 15 min) when in solution at appropriate concentration.
7. Literature / References
Rowe RC, Sheskey PJ, Cook WG, Fenton ME (Eds.) (2012). Handbook of Pharmaceutical Excipients, 7th ed. Pharmaceutical Press. Entry: Mannitol, pp. 424–430.
United States Pharmacopeia (USP). Mannitol Monograph. USP–NF, current edition.
European Pharmacopoeia (EP). Mannitol Monograph. Ph. Eur. 10th edition.
Food Standards Australia New Zealand (FSANZ). Food Additive E421 — Mannitol. FSANZ Food Standards Code, Schedule 15.
European Parliament & Council Regulation (EC) No 1333/2008 on food additives. Annex II: Mannitol (E421).
Technical data based on current scientific knowledge and quality testing. AuSaMicS Pty Ltd | 31 Longview CT, Thomastown VIC 3074 | ABN: 56 676 640 467 | www.ausamics.com.au. For food/excipient use in accordance with applicable regulations.
Safety Data Sheet — Mannitol Powder (ASC-8018)
Prepared in accordance with the Australian Code for the Labelling of Workplace Hazardous Chemicals and GHS. Revision date: 2025.
GHS Classification: Not classified as hazardous under the GHS criteria. No signal word, no hazard statements, no pictograms required. Note: Combustible dust hazard may exist when fine powder is suspended in air at sufficient concentration — standard good housekeeping applies.
Section 3 — Composition
Component
CAS
Formula
Content
D-Mannitol
69-65-8
C₆H₁₄O₆
≥98.0%
Section 4 — First Aid Measures
Inhalation
Remove to fresh air. Mannitol is a food substance — no acute toxicity expected. Seek medical attention if symptoms persist.
Skin Contact
Wash with soap and water. No irritation expected at food-grade concentrations.
Eye Contact
Rinse with water for 15 minutes. Seek medical advice if irritation persists.
Ingestion
Food-approved substance. Excessive ingestion may cause laxative effects. Seek medical advice if symptomatic.
Section 5 — Fire-Fighting Measures
Flammability
Not readily flammable; combustible solid above ~460°C
Extinguishing Media
CO₂, dry powder, foam, water spray
Special Hazards
Fine dust may form explosive mixture — prevent dust accumulation in enclosed spaces
Section 6 — Accidental Release
Sweep or vacuum up carefully to minimise dust. Avoid generating airborne dust. Dispose in accordance with local regulations or reclaim for intended use if uncontaminated.
Section 7 — Handling & Storage
Handling
Handle in well-ventilated areas. Minimise dust generation. Standard food-handling hygiene applies.
Storage
15–25°C, tightly sealed, away from moisture and contamination. Keep away from strong oxidising agents.
Section 8 — Exposure Controls / PPE
Exposure Limits
No specific OEL established. Treat as nuisance dust: TWA 10 mg/m³ (inhalable), 3 mg/m³ (respirable)
Respiratory
Dust mask (P1) if dust generation expected
Hands
Standard food-handling gloves; nitrile recommended for extended contact
Eyes
Safety glasses during powder handling
Section 9 — Physical & Chemical Properties
Appearance
White crystalline powder
Odour
Odourless
Melting Point
165–169°C
Solubility
~182 g/L in water at 25°C
pH (10% aq.)
5.0–8.0
Section 10 — Stability & Reactivity
Stability
Stable under normal conditions
Conditions to Avoid
Prolonged exposure to high humidity, strong oxidisers
This SDS is provided in good faith. Users are responsible for safe handling. AuSaMicS Pty Ltd | 31 Longview CT, Thomastown VIC 3074 | ABN: 56 676 640 467 | www.ausamics.com.au.
Certificate of Analysis — Mannitol Powder (ASC-8018)
Representative COA. Lot-specific COA available upon request via support@ausamics.com.
Product Name
Mannitol Powder
Catalogue Number
ASC-8018
CAS Number
69-65-8
E Number
E421
Lot Number
Available on product label
Manufacture Date
Available on product label
Expiry Date
Available on product label
Supplied by
AuSaMicS Pty Ltd, 31 Longview CT, Thomastown VIC 3074, Australia
Test Results
Test
Specification
Result
Status
Appearance
White crystalline powder
White crystalline powder, free-flowing
✓ PASS
Assay (D-Mannitol)
≥98.0%
≥99.2%
✓ PASS
Loss on Drying
≤0.3%
≤0.15%
✓ PASS
Residue on Ignition
≤0.1%
≤0.05%
✓ PASS
pH (10% aqueous)
5.0–8.0
~6.2
✓ PASS
Optical Rotation [α]D²⁰
+23.0° to +24.0°
+23.5°
✓ PASS
Reducing Sugars
≤0.1%
<0.05%
✓ PASS
Heavy Metals (as Pb)
≤10 ppm
<2 ppm
✓ PASS
Arsenic (as As)
≤1 ppm
<0.1 ppm
✓ PASS
Chloride
≤50 ppm
<20 ppm
✓ PASS
Sulphate
≤100 ppm
<40 ppm
✓ PASS
TPC (Microbial)
≤1000 CFU/g
<100 CFU/g
✓ PASS
E. coli
Absent / 10 g
Not detected
✓ PASS
Salmonella spp.
Absent / 25 g
Not detected
✓ PASS
Conclusion: This batch of Mannitol Powder (ASC-8018) meets all specified food-grade quality criteria and is released for food, nutraceutical, cosmetic, and industrial formulation use. Released by AuSaMicS Quality Control, Thomastown VIC 3074, Australia.
AuSaMicS Pty Ltd | 31 Longview CT, Thomastown VIC 3074 | ABN: 56 676 640 467 | www.ausamics.com.au | support@ausamics.com | +61 412 520 598. For food/formulation use in accordance with applicable regulations.
Cross-Reference / Equivalent Products
The following are equivalent or comparable Mannitol products from major international suppliers. AuSaMicS ASC-8018 is the Australian-stocked alternative — same food-grade and excipient-compatible specification, local availability, same-week Melbourne dispatch.
Supplier
Product Name
Catalogue Number
Grade / Notes
AuSaMicS 🇦🇺
Mannitol Powder
ASC-8018
Food grade / excipient compatible — Australian stock, same-week dispatch, COA included
Sigma-Aldrich / Merck
D-Mannitol
M4125, M9647, 63559
Various grades: ReagentPlus, BioReagent, USP grade
Thermo Fisher Scientific
D-Mannitol
A16006, BP683
ACS grade and USP grade options
Roquette
PEARLITOL® (Mannitol)
PEARLITOL 100 SD, 200 SD, 300 DC
Spray-dried grades specifically designed for direct compression and ODT
SPI Pharma (IFF)
Mannogem™ EZ
Mannogem EZ, Mannogem XL
Pharmaceutical-grade mannitol for direct compression
Cargill
Mannitol (food grade)
Proprietary
Food and nutrition grade, commercial volumes
Univar Solutions (AU)
D-Mannitol
Various
Distributor — food and pharma grades in Australia
TCI Chemicals
D-Mannitol
M0055
Research grade, ≥98%
AppliChem / ITW Reagents
D-Mannitol
A1577
Biochemistry grade
⚠ Note: For pharmaceutical manufacturing applications requiring full USP/EP/BP compliance (parenteral use, ODT), please contact AuSaMicS to confirm the available grade and pharmacopoeial documentation. Food-grade specification is supplied as standard.
Why Choose AuSaMicS?
Australian stock — no import lead times
Same-week dispatch from Melbourne
COA included with every batch
Competitive pricing for small to large quantities
Full documentation: COA, SDS, TDS available
Multiple pack sizes: 100 g to 1 kg
Direct technical support from Australian supplier
Food grade and excipient-compatible specification
Intent-Based Search Queries
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Cross-reference data provided for informational purposes only. Trademark names belong to their respective owners. AuSaMicS Pty Ltd | 31 Longview CT, Thomastown VIC 3074 | ABN: 56 676 640 467 | www.ausamics.com.au | support@ausamics.com | +61 412 520 598. Buyers are responsible for ensuring compliance with applicable food, pharmaceutical, and cosmetic regulations in their jurisdiction.