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Calcium Disodium EDTA (Food Grade) | BA-1024 | E385
  • Calcium Disodium EDTA (Food Grade) | BA-1024 | E385
Calcium Disodium EDTA (Food Grade) | BA-1024 | E385 | AuSaMicS

Calcium Disodium EDTA (Food Grade) | BA-1024 | E385 | AuSaMicS

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AuSaMicS Life Science  ·  Food-Grade Chelating Agent

Calcium Disodium EDTA

EDTA-CaNa₂  ·  Ethylenediaminetetraacetic Acid Calcium Disodium Salt  ·  BA-1024

A food-grade chelating agent used as a preservative, stabiliser, and metal ion sequestrant in food and beverage manufacturing. EDTA-CaNa₂ (also known as Calcium Disodium EDTA) is approved under food additive regulations (E385) and widely used in canned and packaged foods to prevent oxidative rancidity and discolouration caused by trace metal contamination.

Food Grade E385 Approved Chelating Agent In Stock — Melbourne

Product Snapshot

Catalogue No.BA-1024
CAS No.62-33-9
Molecular FormulaC₁₀H₁₂CaN₂Na₂O₈
Mol. Weight410.31 g/mol
GradeFood Grade
E NumberE385
AppearanceWhite crystalline powder
SolubilityFreely soluble in water
DocumentationCOA / TDS / SDS

Overview

Calcium Disodium EDTA (EDTA-CaNa₂, E385) is a food-grade chelating agent that functions by binding free divalent metal ions — particularly iron, copper, manganese, and zinc — in food matrices. By sequestering these pro-oxidant metals, it prevents enzymatic browning, oxidative rancidity, flavour degradation, and discolouration, thereby extending shelf life and preserving the sensory quality of food and beverage products. Unlike Disodium EDTA (Na₂EDTA), the calcium-disodium form does not deplete dietary calcium, making it the preferred choice for food applications under international food additive regulations.
Food Additive E385  ·  CODEX STAN / FSANZ Compliant
Primary Applications
  • Preservation of canned & packaged foods
  • Prevention of oxidative rancidity
  • Colour stabilisation in dressings & sauces
  • Chelation of trace metal contaminants
  • Beverage stabilisation
Industries
  • Food & beverage manufacturing
  • Canned seafood & vegetables
  • Sauces, dressings, condiments
  • Margarine & fats
  • Pharmaceutical excipient use
Key Strengths
  • Calcium-form: dietary Ca not depleted
  • Effective at low use levels (50–75 ppm)
  • Synergistic with antioxidants (BHA, tocopherols)
  • Stable over broad pH range
  • Full food-grade COA supplied

Chemical Identity & Properties

Property Value Notes
IUPAC Name Calcium disodium 2,2′,2′′,2′′′-(ethane-1,2-diyldinitrilo)tetraacetate
Synonyms Calcium Disodium EDTA; CaNa₂EDTA; Edetate Calcium Disodium; Calcium Versene; E385
CAS Number 62-33-9 Anhydrous form
Molecular Formula C₁₀H₁₂CaN₂Na₂O₈ Anhydrous
Molecular Weight 410.31 g/mol Anhydrous; dihydrate = 446.34
Appearance White crystalline powder Odourless, slightly saline taste
Solubility (water) ≥ 100 g/L at 20 °C Freely soluble
pH (1% solution) 6.5 – 7.5 Approximately neutral
Melting point > 220 °C (dec.) Decomposes without melting
Stability Stable under normal conditions Hygroscopic; store sealed

Function & Mechanism of Action

EDTA-CaNa₂ acts as a hexadentate ligand, forming stable 1:1 complexes with divalent and trivalent metal cations (Fe²⁺/³⁺, Cu²⁺, Mn²⁺, Zn²⁺) through four carboxylate groups and two amine nitrogen atoms. In food systems, these free metal ions catalyse lipid oxidation (via Fenton-type reactions) and enzymatic browning (via polyphenol oxidase activation). By sequestering them, EDTA-CaNa₂ interrupts the oxidative cascade at its initiation step. The calcium-sodium salt undergoes transmetallation in food matrices — exchanging its Ca²⁺ for more strongly bound metals — without permanently depleting bioavailable calcium in the final product.
Target Metal Ion Effect Prevented Food Systems Affected Stability Constant (log K)
Fe²⁺ / Fe³⁺ Lipid oxidation, Fenton reaction, colour change Canned seafood, sauces, dressings 14.3 / 25.1
Cu²⁺ Catalytic oxidation, rancidity, off-flavours Margarine, fats, beverages 18.8
Mn²⁺ Enzymatic browning acceleration Fruit products, juices 13.8
Zn²⁺ Enzyme activation, colour destabilisation Dairy analogues, emulsions 16.5
Ca²⁺ (delivered) Calcium released as EDTA sequesters other metals All food matrices 10.7

Typical Use Levels & Regulatory Limits

Food Category Typical Level (ppm / mg/kg) Regulatory Basis Function
Canned shellfish & seafood 250 mg/kg max CODEX STAN 193; FSANZ Schedule 15 Struvite prevention, colour retention
Sauces & dressings 75 mg/kg max CODEX / EU E385 Oxidation prevention, flavour stability
Margarine & fat spreads 100 mg/kg max CODEX STAN 256 Antioxidant synergist
Canned legumes & vegetables 250 mg/kg max CODEX STAN 297 Colour & texture stabilisation
Beverages (non-alcoholic) 33–50 mg/kg Application-specific Metal chelation, clarity
General food use (as permitted) Up to 250 mg/kg GMP / national regulations Preservative, stabiliser
Note: Always verify current maximum permitted levels with the applicable national food standards (FSANZ in Australia, EU regulation EC 1333/2008, or FDA 21 CFR 172.120 in the USA). Use levels must comply with the principle of use at the lowest level technologically necessary.

Comparative Chelating Agents

Agent Form Food Grade E Number Ca Depletion Risk Typical Use Key Difference
EDTA-CaNa₂ (BA-1024) Calcium disodium salt Yes E385 None 50–250 ppm Preferred food form; no Ca depletion
Disodium EDTA (Na₂EDTA) Disodium salt Limited E386 Possible at high dose Lab / pharma Not preferred for food; may bind dietary Ca
Citric Acid Organic acid Yes E330 None 0.1–0.5% Weaker chelator; also acidulant
Phosphoric Acid / Phosphates Inorganic acid/salts Yes E338–341 None Application-specific Broad function; weaker metal binding than EDTA
DTPA Pentaacetic acid derivative Very limited — N/A Industrial/lab Stronger chelator but not food-approved

Advantages & Limitations

Advantages
  • Approved food additive (E385) — internationally recognised
  • Calcium form: does not deplete dietary calcium in food
  • Highly effective at low use levels (50–250 ppm)
  • Synergistic with antioxidants (BHA, BHT, tocopherols)
  • Stable across broad pH and temperature ranges
  • Extends shelf life and preserves sensory quality
  • Well-characterised safety profile (long regulatory history)
  • Freely soluble — easy to incorporate into aqueous systems
Limitations
  • Not permitted in all food categories — verify FSANZ/CODEX limits
  • May reduce bioavailability of mineral micronutrients at high doses
  • Not effective against lipid oxidation already initiated
  • Not suitable for products marketed as "additive-free" or "clean label"
  • Environmental persistence — non-biodegradable; dispose per regulations
  • Requires accurate dosing — overuse can cause off-flavours

Cross-Reference / Equivalent Products

Supplier Product Name Catalogue No. Notes
Sigma-Aldrich / Merck Calcium disodium EDTA E4145 Reagent grade; also food-grade available
Thermo Fisher Edetate Calcium Disodium Salt 10697683 Food/pharma grade
Chem-Supply (AU) EDTA Calcium Disodium Salt CE037 Australian supplier

Specifications at a Glance

CAS No.62-33-9
GradeFood Grade
E NumberE385
Purity≥ 99.0 %
pH (1%)6.5 – 7.5
Loss on drying≤ 13.0 %
Heavy metals≤ 10 ppm
Arsenic≤ 3 ppm
Pack sizes100 g · 500 g · 1 kg
Food Safety & Compliance
  • E385 — EU / CODEX approved
  • FDA 21 CFR 172.120
  • FSANZ Schedule 15 (Australia)
  • Halal & Kosher compatible
  • Non-GMO
  • COA with every batch

Storage

Condition15–25 °C, dry, sealed
HumidityKeep away from moisture (hygroscopic)
ContainerTight-sealed HDPE or original packaging
Shelf life3 years from manufacture date
For food manufacturing and laboratory use. Always comply with applicable food additive regulations and maximum permitted levels. Not for direct consumer sale as a standalone additive.
Contact & Support
support@ausamics.com.au
+61 412 520 598
31 Longview CT, Thomastown VIC 3074

Mode of Action

EDTA-CaNa₂ functions as a hexadentate chelating agent, forming highly stable 1:1 octahedral complexes with divalent and trivalent metal cations via four acetate carboxylate groups and two nitrogen atoms of the ethylenediamine backbone. In food matrices, free metal ions — particularly Fe²⁺/³⁺ and Cu²⁺ — catalyse lipid peroxidation through Fenton and Haber-Weiss reactions. By sequestering these ions, EDTA-CaNa₂ removes the catalytic species before oxidation is initiated. The Ca²⁺ moiety undergoes competitive displacement by higher-affinity metals (Fe, Cu), releasing Ca²⁺ into the food system — this transmetallation mechanism is the reason dietary calcium is not depleted and why this form is preferred over Disodium EDTA (E386) in food applications.

Physical & Chemical Specifications

Parameter Specification Test Method
Assay (anhydrous basis) ≥ 99.0 % Complexometric titration (EDQM/USP)
Appearance White crystalline powder, odourless Visual
pH (1% aqueous, 20 °C) 6.5 – 7.5 Calibrated pH meter
Loss on drying (105 °C, 4 h) ≤ 13.0 % Gravimetric
Calcium content 9.7 – 10.3 % AAS or complexometric titration
Sodium content 11.0 – 11.8 % AAS or flame photometry
Solubility in water ≥ 100 g/L at 20 °C Gravimetric dissolution
Heavy metals (as Pb) ≤ 10 ppm ICP-MS or AAS
Arsenic (As) ≤ 3 ppm ICP-MS or hydride generation AAS
Lead (Pb) ≤ 2 ppm ICP-MS
Iron (Fe) ≤ 5 ppm ICP-OES
Nitrilotriacetic acid (NTA) Not detectable HPLC

Dissolution & Preparation Guidelines

1
Weigh
Accurately weigh required quantity per formulation
›
2
Dissolve
Add to purified / RO water at room temperature
›
3
Mix
Stir gently until fully dissolved (dissolves readily)
›
4
Adjust pH
Adjust to desired process pH if required
›
5
Add to Batch
Incorporate into food system as per formulation
EDTA-CaNa₂ is typically added in dissolved form to avoid uneven distribution. It is compatible with most food processing temperatures and is stable during pasteurisation and sterilisation. Avoid prolonged contact with concentrated mineral acids.

Literature & References

1. FAO/WHO Joint Expert Committee on Food Additives (JECFA). Calcium Disodium EDTA. WHO Technical Report Series, No. 940 (2007). Available at: www.who.int/foodsafety/publications/jecfa

2. European Food Safety Authority (EFSA). Re-evaluation of EDTA and its sodium and potassium salts (E385). EFSA Journal, 2022; 20(3):7157.

3. Food Standards Australia New Zealand (FSANZ). Food Additives Schedule — Schedule 15, Standard 1.3.1. Available at: www.foodstandards.gov.au

4. U.S. FDA. 21 CFR 172.120 — Calcium disodium EDTA. Code of Federal Regulations, Title 21.

5. Graf, E. (1992). Antioxidant potential of ferulic acid. Free Radical Biology and Medicine, 13(4), 435–448. (Cited for EDTA synergy with antioxidants in food systems.)

Ordering Info

SKUBA-1024
Pack sizes100 g · 500 g · 1 kg
GradeFood Grade
DocumentsCOA · TDS · SDS
DispatchMelbourne, same week
Technical Notes
  • Hygroscopic — store in sealed container
  • Not for use above maximum permitted levels
  • Verify regulatory limits per target market
  • Incompatible with strong oxidising agents
  • Contact us for bulk pricing > 5 kg

Certificate of Analysis — Release Specifications

Test Parameter Specification Method Status
Assay (anhydrous) ≥ 99.0 % Complexometric titration Release tested
Appearance White crystalline powder Visual inspection Release tested
pH (1%, 20 °C) 6.5 – 7.5 Calibrated pH meter Release tested
Loss on drying ≤ 13.0 % 105 °C / 4 h Release tested
Calcium content 9.7 – 10.3 % Complexometric titration / AAS Release tested
Heavy metals (as Pb) ≤ 10 ppm ICP-MS Release tested
Arsenic ≤ 3 ppm Hydride generation AAS Release tested
Lead ≤ 2 ppm ICP-MS Release tested
NTA (nitrilotriacetic acid) Not detectable HPLC Release tested
Each batch is assigned a unique lot number. COA available on request or as a download from the product page. Testing performed in accordance with JECFA / FCC (Food Chemicals Codex) monograph specifications.

Quality Standards & Compliance

Standard / Regulation Status
Food Chemicals Codex (FCC) Compliant
JECFA (WHO/FAO) Compliant
EU E385 (Reg. EC 1333/2008) Compliant
FSANZ Schedule 15 Compliant
FDA 21 CFR 172.120 Compliant
Batch Traceability

Every batch of BA-1024 is assigned a unique lot number traceable to raw material intake records, testing data, and production date.

Certificate of Analysis (COA) is issued for every batch and includes all release test results, lot number, manufacture date, and expiry date.

Hazard Classification

GHS Classification: Not classified as hazardous under GHS (Globally Harmonised System).

Signal Word: None

Hazard Statements: None applicable under current classification

ADG Transport Class: Not classified as dangerous goods

Precautionary Measures: Avoid inhalation of dust. Use in well-ventilated area. Wear gloves and eye protection during weighing and handling. Wash hands thoroughly after use.

GHS Sections Summary

Section Key Information
1 — Identification Calcium Disodium EDTA, BA-1024, AuSaMicS Pty Ltd
2 — Hazard ID Not classified as hazardous (GHS)
3 — Composition C₁₀H₁₂CaN₂Na₂O₈; CAS 62-33-9; Food grade
4 — First Aid Skin/eye: flush with water. If ingested: seek medical advice if symptomatic
5 — Fire Fighting Non-flammable; use water, CO₂, or dry chemical for surrounding fire
6 — Spill Sweep up dry material; avoid dispersal of dust; dispose per Section 13
7 — Handling Avoid dust generation; store in sealed containers away from moisture
8 — Exposure Controls Local exhaust ventilation; P2 dust mask if dust generated; nitrile gloves
12 — Ecological Persistent chelating agent — do not release to waterways in excess quantities
13 — Disposal Dilute solutions may be disposed via sewer (check local regulations). Dry waste: licensed waste contractor
15 — Regulatory AICIS (Australia) compliant; Food additive E385; FDA 21 CFR 172.120
Full 16-section GHS-compliant Safety Data Sheet (SDS) is available as a downloadable PDF from the AuSaMicS product page or upon request. Contact support@ausamics.com.au for batch-specific documentation including COA.
DISCLAIMER: This product is intended for food manufacturing and professional laboratory use by trained personnel. AuSaMicS Pty Ltd makes no representations regarding fitness for a particular purpose beyond the stated intended use. Users bear full responsibility for verifying compliance with applicable food additive regulations in their target market, including maximum permitted levels. AuSaMicS Pty Ltd shall not be liable for any direct, indirect, or consequential damages arising from misuse, misapplication, or non-compliance with applicable regulations. © AuSaMicS Pty Ltd. All rights reserved. ABN: 56 676 640 467.

 

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