Fosfomycin Disodium Powder
$0.00 AUD
Product Identification
| Catalog Number | AS-2032 |
| CAS Number | 26016-99-9 |
| Molecular Formula | C₃H₅Na₂O₄P |
| Molecular Weight | 182.02 g/mol |
| Grade | Laboratory Grade |
| Purity | ≥ 98% (HPLC) |
| Intended Use | For Laboratory Use Only — Not for human or veterinary use |
Description
Fosfomycin Disodium Powder (CAS 26016-99-9) is a water-soluble sodium salt of fosfomycin, a naturally occurring phosphonic acid antibiotic. The disodium form provides excellent aqueous solubility, making it ideal for preparation of working solutions in microbiological and biochemical research.
Fosfomycin disodium exerts bactericidal activity by covalently and irreversibly inhibiting MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) — the enzyme catalysing the first committed step in bacterial peptidoglycan biosynthesis. This unique mechanism confers broad-spectrum activity against both Gram-positive and Gram-negative organisms with minimal cross-resistance to other antibiotic classes.
In translational research, fosfomycin disodium is widely studied as an effective agent against multidrug-resistant organisms (MDROs) including ESBL-producing Escherichia coli and vancomycin-resistant Enterococcus faecalis.
Research Applications
| Application Area | Details |
|---|---|
| Antimicrobial Research | Study of MurA inhibition and peptidoglycan biosynthesis pathways. |
| Selective Culture Media | Incorporated into microbiological media for isolation of resistant strains. |
| Susceptibility Testing | MIC determination and disk diffusion assays per EUCAST/CLSI guidelines. |
| MDR Organism Studies | Research involving ESBL-producing E. coli, MRSA, and VRE. |
| Pharmaceutical Development | Reference standard for formulation studies and analytical validation. |
Storage & Stability
| Storage | –20 °C, desiccated, in original sealed container |
| Shelf Life | 24 months from date of manufacture |
| Solubility | Freely soluble in water; slightly soluble in ethanol |
⚠ For Laboratory Use Only. This product is not approved for human or veterinary therapeutic use. Handle in accordance with standard laboratory safety protocols.
Physical & Chemical Properties
| Appearance | White to off-white crystalline powder |
| Odour | Odourless |
| Solubility | Freely soluble in water; slightly soluble in ethanol; insoluble in acetone |
| pH (10 mg/mL aq.) | 9.0 – 10.5 |
| Melting Point | >200 °C (decomposition) |
| Density | Approx. 1.84 g/cm³ |
| Hygroscopicity | Hygroscopic — store desiccated |
| Partition Coefficient (log Kow) | –3.1 (estimated) |
Purity & Quality Specifications
| Test | Specification | Method |
|---|---|---|
| Purity (HPLC) | ≥ 98.0% | HPLC-UV, 210 nm (C18) |
| Water Content | ≤ 2.0% | Karl Fischer Titration |
| Heavy Metals | ≤ 10 ppm | ICP-MS |
| Residue on Ignition | ≤ 0.5% | USP <281> |
| Microbial Limit (TVC) | ≤ 100 CFU/g | USP <61> |
Microbiological Activity — Indicative MIC Values
| Organism | MIC Range (µg/mL) | Notes |
|---|---|---|
| E. coli ATCC 25922 | 0.5 – 4 | EUCAST susceptibility breakpoint ≤ 32 µg/mL |
| E. faecalis ATCC 29212 | 8 – 64 | Active against VRE strains |
| S. aureus (MRSA) | 16 – 128 | Synergy with beta-lactams reported |
| K. pneumoniae | 4 – 32 | ESBL strains typically susceptible |
| P. aeruginosa | 32 – 256 | Moderate; combination use advised |
Preparation of Working Solutions
Aqueous Stock (recommended)
Dissolve in sterile Milli-Q water or PBS (pH 7.4) at 50–100 mg/mL. Vortex until dissolved. Filter-sterilise through 0.22 µm PES membrane. Aliquot into single-use volumes and store at –20 °C. Avoid repeated freeze–thaw cycles.
Incompatibilities
Avoid strong oxidising agents, acidic conditions (pH <4), and calcium-containing solutions (precipitation risk).
This Technical Data Sheet is provided for informational purposes and represents typical values. AuSaMiCS Pty Ltd reserves the right to update specifications without notice. For lot-specific data, refer to the Certificate of Analysis.
Section 1 — Identification
| Product Name | Fosfomycin Disodium Powder |
| Catalog Number | AS-2032 |
| CAS Number | 26016-99-9 |
| Recommended Use | Laboratory research use only |
| Supplier | AuSaMiCS Pty Ltd, 31 Longview CT, Thomastown VIC 3074, Australia |
| Emergency | Poisons Information Centre: 13 11 26 (Australia, 24 hr) |
Section 2 — Hazard Identification
Based on available data, Fosfomycin Disodium Powder is NOT classified as a hazardous substance under the GHS / Australian WHS Regulations 2017 at typical laboratory research quantities. No hazard pictograms or signal words are required.
Precautionary Statements (Prudent Laboratory Practice)
P260 Do not breathe dust. | P264 Wash hands after handling. | P270 Do not eat/drink/smoke when using. | P501 Dispose per local regulations.
Sections 4–8 — First Aid, Fire, Spill, Handling & PPE (Summary)
| Topic | Key Guidance |
|---|---|
| Inhalation | Remove to fresh air. Seek medical attention if symptoms persist. |
| Skin Contact | Wash with soap and water ≥ 15 min. Remove contaminated clothing. |
| Eye Contact | Irrigate with water ≥ 15 min. Seek immediate medical attention. |
| Ingestion | Do not induce vomiting. Seek medical attention. |
| Fire | Not flammable. Decomposes >200 °C. Use CO₂ or dry chemical powder. |
| Spill | Sweep up, avoid dust. Collect in labelled waste container. Avoid drain entry. |
| PPE | Nitrile gloves, safety goggles, lab coat. Use fume cupboard when weighing. |
Section 14 — Transport
Not classified as dangerous goods under ADG, IATA, or IMDG at research quantities.
Section 15 — Regulatory
| WHS Regulations 2017 | Compliant — not classified as hazardous |
| SUSMP | Schedule 4 in therapeutic formulations only; NOT applicable to this laboratory reagent |
| ARTG / TGA | Not registered — laboratory use only |
This is a summary SDS preview. The full GHS-compliant 16-section Safety Data Sheet, prepared in accordance with Australian WHS Regulations 2017, is available for download above. Issue Date: March 2025 | Version 1.0
Lot & Product Details
| Product Name | Fosfomycin Disodium Powder |
| Catalog Number | AS-2032 |
| Lot Number | AS2032-250301 |
| CAS Number | 26016-99-9 |
| Date of Manufacture | March 2025 |
| Expiry Date | March 2027 |
| Storage | –20 °C, desiccated, original sealed container |
Quality Test Results
| Test Parameter | Specification | Result | Method |
|---|---|---|---|
| Appearance | White to off-white powder | CONFORMS | Visual inspection |
| Identity (FT-IR) | Consistent with reference | CONFORMS | FT-IR spectroscopy |
| Identity (HPLC RT) | RT ± 2% of reference | CONFORMS | HPLC-UV 210 nm |
| Purity (HPLC Area %) | ≥ 98.0% | 99.3% | HPLC-UV, C18 column |
| Water Content (KF) | ≤ 2.0% | 0.8% | Karl Fischer Titration |
| Residue on Ignition | ≤ 0.5% | 0.12% | USP <281> |
| Heavy Metals | ≤ 10 ppm | < 5 ppm | ICP-MS |
| pH (10 mg/mL aq.) | 9.0 – 10.5 | 9.6 | Calibrated pH meter |
| Solubility | Freely soluble in water | CONFORMS | Visual dissolution test |
| Microbial Limit (TVC) | ≤ 100 CFU/g | < 10 CFU/g | USP <61> |
✓ ALL TESTS PASSED — LOT AS2032-250301 RELEASED FOR USE
Authorisation
| Analysed By | AuSaMiCS Quality Control Laboratory |
| Authorised By | Hassan Salimi, Founder & Technical Director, AuSaMiCS Pty Ltd |
| Date of Issue | March 2025 |
| COA Reference | AS2032-250301-COA-001 |
This Certificate of Analysis is specific to Lot AS2032-250301 and reflects the condition of the product at the time of QC testing and release. Results are not transferable to other lots. AuSaMiCS Pty Ltd certifies the accuracy of this document. Unauthorised reproduction or alteration is strictly prohibited. © 2025 AuSaMiCS Pty Ltd.