Amphotericin B Powder

Amphotericin B Powder – Research-Grade Antifungal

Catalog Number: AS-2002
CAS Number: 1397-89-3
Molecular Weight: 924.10 g/mol
Molecular Formula: C₄₇H₇₃NO₁₇

Overview

Amphotericin B is a potent, broad-spectrum polyene antifungal antibiotic produced by Streptomyces nodosus. It is widely used in microbiology and pharmaceutical research due to its strong activity against yeasts and filamentous fungi.

The compound functions by binding to ergosterol, a critical component of fungal cell membranes. This interaction creates transmembrane pores, leading to leakage of essential ions and metabolites, ultimately resulting in fungal cell death. Because mammalian cells contain cholesterol instead of ergosterol, Amphotericin B shows selective antifungal activity.

Key Features

• Broad-spectrum polyene antifungal agent

• High affinity for fungal membrane ergosterol

• Effective against yeasts and molds

• Widely used reference compound in antifungal research

• Supplied as research-grade powder

Applications

• Antifungal susceptibility testing

• Research on fungal membrane biology

• Development and screening of antifungal agents

• Selective suppression of fungal contamination in laboratory studies

• Pharmaceutical and biochemical research

Storage & Handling

• Store tightly sealed in a cool, dry place

• Protect from light and moisture

• Prepare solutions freshly or store aliquots according to experimental requirements

Intended Use

For laboratory and research use only.
Not for human or veterinary use.