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Mebendazole – High-Purity Lab-Grade Reagent (AS-2052) Parasitology
$39.00 AUD
AuSaMicS Life Science™ · Benzimidazole Compounds · Research Grade Reagents
Mebendazole ≥99% EP Grade
Methyl 5-benzoyl-1H-benzimidazole-2-carbamate | CAS: 31431-39-7 | Cat: ASA-2052
High-purity mebendazole manufactured to European Pharmacopoeia standards, verified at ≥99% by HPLC. Australian stock held in Thomastown, VIC — ready for same-day dispatch to universities, pharmaceutical QC laboratories, and research institutions across Australia.
≥99% EP Grade
✓ In Stock Australia
⚡ Same-Day Dispatch
📋 COA + SDS Included
🔬 Research Use Only
Quick Specs
CAS Number31431-39-7
CatalogueASA-2052
MW295.30 g/mol
FormulaC₁₆H₁₃N₃O₃
Purity≥99% (HPLC)
GradeEuropean Pharmacopoeia
HS Code2933.29.00
Overview
Mebendazole (ASA-2052) is a benzimidazole carbamate compound with a well-established role in parasitological and pharmacological research. Manufactured to European Pharmacopoeia (EP) grade standards and verified at ≥99% purity by HPLC, this product delivers consistent, reproducible performance across a wide range of in vitro research models.
Supplied as a fine white to off-white crystalline powder, mebendazole is stable under standard laboratory conditions and soluble in DMSO and acetic acid. Complete analytical documentation — including Certificate of Analysis (COA) and Safety Data Sheet (SDS) — is included with every order. Stock is held in Melbourne, Australia, enabling same-day dispatch with no import delays.
Research Applications
Parasitology & Anthelmintic Research
Reference standard for in vitro studies on nematode, cestode, and trematode biology; anthelmintic mechanism characterisation and resistance profiling.
Microtubule & Cytoskeletal Studies
Investigation of tubulin-binding pharmacology, microtubule polymerisation inhibition, and mitotic spindle disruption across helminth and mammalian cell systems.
Pharmacology & Drug Metabolism
ADMET profiling, metabolite identification (hydroxy-mebendazole, amino-mebendazole), comparative bioavailability studies, and polymorphic form analysis (A, B, C).
Formulation Development
Evaluation of solubility enhancement strategies, co-crystal formation, nanoparticle formulation, and bioavailability improvement for poorly water-soluble benzimidazoles.
Pharmaceutical QC & Reference
High-purity EP-grade material suitable as analytical reference standard for method development, validation, and regulatory compliance testing in pharma QC laboratories.
Academic & Institutional Research
Extensively cited in peer-reviewed literature as a model benzimidazole for studies in drug-resistance mechanisms, anti-parasitic pharmacodynamics, and comparative biochemistry.
Why Choose AuSaMicS Mebendazole ASA-2052?
| Purity Guarantee | ≥99% by HPLC — EP Grade standard, batch-verified |
| Supply Chain | Australian-held stock in Melbourne — no 4–6 week import wait |
| Documentation | Full COA, SDS (GHS/WHS compliant), and TDS supplied with every order |
| Batch Consistency | Each lot independently tested; results available on request |
| Formulation Guidance | Direct technical support from the product formulator — not a call centre |
| Dispatch Speed | Same-day dispatch for orders placed before 12:00 PM AEST (Melbourne) |
Cross-Reference / Equivalent Products
AuSaMicS Mebendazole ASA-2052 is comparable to the following commercial reference materials. Supplied from Australian stock with full documentation and direct formulator support.
| Supplier | Product Name / Cat. No. | Purity | AU Stock | Same-Day Dispatch |
|---|---|---|---|---|
| AuSaMicS Life Science ← You are here | Mebendazole ASA-2052 | ≥99% EP Grade | ✔ Melbourne | ✔ Yes |
| Sigma-Aldrich (Merck) | Mebendazole M2523 | ≥98% (HPLC) | Import | ✗ No |
| Cayman Chemical | Mebendazole 14325 | ≥98% | Import | ✗ No |
| TCI Chemicals | Mebendazole M0350 | ≥98.0% (HPLC) | Import | ✗ No |
| Alfa Aesar (Thermo) | Mebendazole J64003 | 98% | Import | ✗ No |
Search & Discovery
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- mebendazole COA included Australia
- anthelmintic reference standard Australia
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- ASA-2052 AuSaMicS
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Chemical Identity
| IUPAC Name | Methyl N-(5-benzoyl-1H-benzimidazol-2-yl)carbamate |
| Common Names | Mebendazole; Mebendazolum; MBZ; R17635; Vermox® (veterinary/clinical ref) |
| CAS Number | 31431-39-7 |
| Molecular Formula | C₁₆H₁₃N₃O₃ |
| Molecular Weight | 295.30 g/mol |
| InChI Key | OPXLLQIJSORQAM-UHFFFAOYSA-N |
| HS Code | 2933.29.00 |
Physical & Chemical Properties
| Appearance | White to off-white crystalline powder |
| Purity | ≥99% (HPLC) — European Pharmacopoeia Grade |
| Melting Point | 288–290 °C (dec.) |
| Polymorphic Forms | Forms A, B, C known; Form C most pharmacologically active |
| Log P (calc.) | 2.83 |
| pKa (calc.) | ~5.0 (benzimidazole N-H) |
Solubility Profile
Water
Practically insoluble (<0.1 mg/mL)
DMSO
Soluble (~10 mg/mL)
Acetic Acid
Soluble
Ethanol 95%
Slightly soluble
Methanol
Slightly soluble
Chloroform
Slightly soluble
Working solution tip: Prepare a 10 mM stock solution in DMSO. For aqueous media, dilute to <0.1% DMSO final concentration. For enhanced aqueous solubility, use acetic acid/buffer systems or consider co-solvent approaches. Contact our technical team for specific protocol guidance.
Quality & Analytical Data
| Identity Method | IR Spectroscopy, HPLC retention time, NMR (on request) |
| Purity Method | Reverse-phase HPLC (C18 column) |
| Residual Solvents | Below ICH Q3C Class 3 limits |
| Heavy Metals | Tested; compliant with EP limits |
| Water Content (KF) | ≤0.5% |
Storage, Handling & Stability
Storage conditions: Store in a cool, dry place (15–25 °C), protected from direct light and moisture. Keep container tightly closed. Under recommended conditions the powder is stable for ≥24 months from manufacture date (see COA for exact expiry).
| Storage Temperature | 15–25 °C (ambient, controlled) |
| Light Sensitivity | Moderate — store away from UV |
| Moisture Sensitivity | Low — desiccant recommended for long-term storage |
| Shelf Life | ≥24 months under recommended conditions |
| GHS Signal Word | Warning |
| GHS Hazard Codes | H302 (Harmful if swallowed); H361 (Suspected reproductive toxicant) |
| PPE Required | Lab coat, nitrile gloves, safety glasses; work in ventilated area |
Mode of Action
Mebendazole exerts its primary pharmacological action through selective, irreversible binding to β-tubulin at the colchicine-binding site. This binding inhibits tubulin polymerisation into microtubules, disrupting the cytoskeletal architecture required for cell division, intracellular transport, and glucose uptake in susceptible organisms.
Mebendazole binds β-tubulin (colchicine-binding site, irreversible)
↓
Inhibition of tubulin polymerisation into microtubules
↓
Disruption of mitotic spindle & cytoskeletal integrity
↓
Impaired glucose transport → depletion of glycogen stores
↓
Energy depletion → cell death (parasite or target cell model)
Unlike fenbendazole, mebendazole binds tubulin irreversibly and with notably higher selectivity for parasite versus mammalian tubulin isoforms. Mebendazole also exists in three polymorphic forms (A, B, C), with Form C demonstrating the highest biological activity — a factor relevant to formulation and in vitro research design.
Technical Overview
| Pharmacological Class | Benzimidazole carbamate; β-tubulin polymerisation inhibitor |
| Primary Target | β-tubulin (colchicine-binding site, irreversible binding) |
| Binding Type | Irreversible (vs fenbendazole which is reversible) |
| IC₅₀ (tubulin polymerisation) | ~0.5–5 µM (species and cell-line dependent) |
| Selectivity | Parasite >> mammalian tubulin; polymorphic form-dependent |
| Key Metabolites | Hydroxy-mebendazole (active); Amino-mebendazole |
| Polymorphic Forms | A (stable), B (metastable), C (most active — triclinic) |
| Typical Working Conc. | 0.1–50 µM depending on assay system |
| Vehicle Recommendation | DMSO stock (10 mM); dilute to <0.1% DMSO in assay media |
Selected Literature References
- Lacey, E. (1990). Mode of action of benzimidazoles. Parasitology Today, 6(4), 112–115.
- Borgers, M., & De Nollin, S. (1975). Ultrastructural changes in Ascaris suum intestine after mebendazole treatment in vivo. Journal of Parasitology, 61(1), 110–122.
- Friedman, P.A., & Platzer, E.G. (1978). Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin. Biochimica et Biophysica Acta, 544(3), 605–614.
- Čulić, O., Eraković, V., & Parnham, M.J. (2001). Anti-inflammatory effects of macrolide antibiotics. European Journal of Pharmacology, 429(1–3), 209–229.
- Duthaler, U., et al. (2010). Pharmacokinetics of oral mebendazole in healthy volunteers: influence of food and mebendazole polymorph. British Journal of Clinical Pharmacology, 69(3), 259–267.
- Bai, R.Y., et al. (2015). Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro-Oncology, 13(9), 974–982.
Available Pack Sizes
| Pack Size | Recommended For | Typical Use Case |
|---|---|---|
| 5 g | Trial / Method Development | Protocol optimisation, initial feasibility testing, student projects |
| 25 g ⭐ Popular | Standard Laboratory Use | Ongoing research programmes, mid-scale in vitro assays |
| 100 g | Extended / Institutional Supply | Core facilities, multi-project departments, long-term programmes; best value per gram |
| Custom | Bulk / Bespoke | Contact us for quantities above 100 g or custom pack requirements |
Custom quantities available. For pack sizes above 100 g or specific formulation requirements, request a quote. AuSaMicS supplies direct from our Thomastown facility — no third-party distributor markup.
Order Information
| Catalogue Number | ASA-2052 |
| Dispatch | Same-day for orders placed before 12:00 PM AEST (Melbourne, weekdays) |
| Shipping | Australia-wide via registered courier; cold-pack not required |
| Minimum Order | 5 g |
| Payment | Credit card, EFT, purchase order (approved institutional accounts) |
| COA | Provided with every shipment; additional batch reports available on request |
| Quote / Bulk Orders | ausamics.com.au/pages/request-a-quote |
Available Documents
Every order of Mebendazole ASA-2052 includes a full analytical and safety documentation package. Documents can also be requested by email prior to purchase.
| Certificate of Analysis (COA) | Batch-specific HPLC purity result, identity confirmation, lot number, expiry date. Request COA for specific lot → |
| Safety Data Sheet (SDS) | Full 16-section GHS/WHS 2023 compliant SDS (Australian format). Download SDS → |
| Technical Data Sheet (TDS) | Detailed physicochemical data, solubility guide, polymorphic form data, storage conditions, and handling recommendations. |
| Product Datasheet (PD) | Summary product information for institutional procurement and record-keeping. |
Document requests: Email support@ausamics.com.au with your catalogue number and lot (if known). All documents dispatched within one business day. For institutional procurement teams requiring pre-purchase documentation, we supply all documents on request prior to order placement.
Regulatory & Compliance Notes
| Standard Applied | European Pharmacopoeia (EP) monograph requirements |
| GHS Classification (AU) | WHS Regulations 2017 (Cth); GHS 7th Edition |
| SUSMP Classification | Schedule 4 (Prescription Only) for therapeutic use — confirm current schedule before ordering for research |
| REACH / TGA | Supplied for research use — not TGA registered as a therapeutic good |
| Customs/Import | Not applicable — Australian domestic stock |
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