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Nutrient Agar with MUG

Nutrient Agar with MUG | AS-1308 | Rapid E. coli Detection | AuSaMicS

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AuSaMicS Life Science • Fluorogenic Media

Nutrient Agar with MUG

4-Methylumbelliferyl-β-D-glucuronide Fluorogenic Medium

Rapid E. coli detection via β-glucuronidase activity with brilliant UV fluorescence. Non-selective formulation ensures maximum recovery of heat-stressed and sublethally injured cells from food and water samples.

AS-1308 366nm UV ✓ Australian Stock 💡 Fluorogenic
Same-Day Dispatch: Australian Stock Food Grade: FDA-BAM compliant Rapid Results: 4-24 hour detection

 E. coli Specialist

Fluorogenic Expert - UV detection system
High Recovery - Stressed cell detection
Complete Package - COA + Protocols
Fast Supply - Ships within 24h
Expert Support - Method optimization
UV Fluorescent
Bright blue-white glow

 Complete Formulation & Fluorogenic Mechanism

📋 Ingredient Composition (per Liter)

Ingredient Concentration Primary Function Purpose
Peptone (Casein) 5.0 g Nitrogen source Enzymatic digest, amino acids, peptides
Beef Extract 3.0 g Nutrient base Vitamins, minerals, growth factors
Sodium Chloride 5.0 g Osmotic balance Maintains cell integrity
Agar 15.0 g Solidifying agent Gel matrix for plate culture
MUG (4-Methylumbelliferyl-β-D-glucuronide) 100 mg/L Fluorogenic substrate β-Glucuronidase detection, UV fluorescence

💡 Fluorogenic Detection Mechanism

E. coli β-glucuronidase enzyme

MUG → 4-Methylumbelliferone + Glucuronic acid

Bright blue-white fluorescence (366nm UV)
Critical: >97% of E. coli strains are GUD positive (Exception: E. coli O157:H7 typically GUD negative)

📊 Complete E. coli Detection Media Portfolio

Medium Selectivity Detection Method Recovery Rate Key Advantage Standards
Nutrient Agar + MUG Non-selective 💡 UV fluorescence 95-99% Maximum stressed cell recovery FDA-BAM, ISO 16649
TBX Agar Highly selective 🔵 Blue colonies 85-92% Direct chromogenic count ISO 16649-2
MacConkey + MUG Selective 🟣 Pink + UV 80-88% Lactose differentiation Traditional methods
Chromocult TBX Highly selective 🔵 Blue-green 88-94% Enhanced specificity EN ISO 16649-2
VRB + MUG Agar Selective 🟣 Purple + UV 82-90% Coliform enumeration APHA methods
Endo Agar Selective 🔴 Red sheen 75-85% Historical standard Legacy methods
EC Medium + MUG Selective 💡 Broth + UV 85-93% Elevated temperature (44.5°C) APHA 9221F

 Strategic Method Selection Guide

✅ Nutrient Agar + MUG Advantages

  • Maximum Recovery: 95-99% for stressed cells
  • Non-Selective Base: No inhibition of injured cells
  • Rapid Detection: Results in 4-24 hours
  • Cost Effective: Simple, economical formulation
  • Heat-Stressed Cells: Ideal for processed foods
  • Universal Application: Food, water, clinical

⚠️ Method Considerations

  • Background Growth: Non-coliforms also grow
  • UV Equipment Required: 366nm longwave lamp
  • O157:H7 Exception: Typically GUD negative
  • Confirmation Needed: Presumptive test only
  • Light Sensitivity: MUG degrades over time

🎯 When to Choose Each Method

  • Nutrient+MUG: Heat-treated/processed foods
  • TBX: Raw foods, direct enumeration
  • MacConkey+MUG: Mixed flora samples
  • Chromocult: Enhanced specificity needed
  • EC+MUG: Thermotolerant confirmation

📊 Sample-Specific Performance Matrix

Sample Type Recommended Medium Recovery % Key Consideration
Heat-Treated Foods Nutrient + MUG 95-99% Sublethally injured cells
Frozen Foods Nutrient + MUG 92-97% Freeze-thaw damage repair
Raw Vegetables TBX or Nutrient+MUG 85-95% Background flora consideration
Ground Beef TBX preferred 85-92% High background flora
Water Samples Nutrient + MUG 90-96% Environmental stress factors
Clinical Specimens MacConkey + MUG 80-88% Need lactose differentiation

🔬 UV Detection Protocol & Quality Control

UV Lamp Specs:
366nm longwave
15W minimum output
Reading Conditions:
Dark room environment
6-12 inch distance
Positive Control:
E. coli ATCC 25922
Bright blue fluorescence
Negative Control:
Enterobacter aerogenes
No fluorescence

📋 Technical Specifications

Catalogue Number AS-1308
Base Weight 28.0 g/L (with MUG)
Final pH 7.0 ± 0.2 (at 25°C)
MUG Concentration 100 mg/L
Appearance (Powder) Cream to light tan
Prepared Medium Clear, light amber
Sterilization 121°C, 15 minutes
Incubation 35-37°C, 18-24 hours
Shelf Life 3 years

 Fluorescent Detection

  • Excitation: 366nm UV longwave
  • Emission: 445nm blue-white
  • Intensity: Brilliant fluorescence
  • Detection Time: 4-24 hours
  • Specificity: >97% E. coli positive

 Critical Success Factors

  • Temperature: Add MUG after cooling to 50°C
  • Light Protection: Store plates in darkness
  • UV Lamp: 366nm longwave essential
  • Timing: Read at 4-6h and 18-24h🔍 Confirmation: Consider O157:H7 testing

 Regulatory Standards

  • FDA BAM Chapter 4A - E. coli detection
  • ISO 16649-3:2015 - MUG method
  • USDA-FSIS MLG 5B - Meat products
  • APHA Standard Methods - Water testing
  • Health Canada MFHPB-27 - Food methods

✅ Quality Standards

  • Performance Testing: Reference strains
  • MUG Potency: Fluorescence verification
  • pH Verification: 7.0 ± 0.2 confirmed
  • Sterility Testing: USP <71> compliant
  • Stability Studies: 36 months validated

 Complete E. coli Detection System

E. coli Detection Media

TBX Agar

Chromogenic detection

View Product
Chromocult TBX

Enhanced selectivity

View Product
MacConkey + MUG

Selective fluorogenic

View Product
EC Medium + MUG

Thermotolerant broth

View Product

Supporting Reagents & Equipment

MUG Substrate

Pure fluorogenic substrate

View Product
UV Lamps (366nm)

Longwave UV detection

View Product
Peptone Water

Sample dilution medium

View Product
Nutrient Broth

Enrichment medium

View Product

Confirmation & Identification

Indole Reagent

Biochemical confirmation

View Product
Methyl Red Reagent

IMVIC testing

View Product
API 20E Strips

Species identification

View Product
E. coli O157:H7 Latex

Pathogenic strain detection

View Product

Need E. coli Detection Support?

Our food safety microbiologists can help optimize your fluorogenic detection protocols

For food safety testing and laboratory use only. Not for food, feed, household, cosmetic, therapeutic, or personal use.
AuSaMicS Pty Ltd • ABN: 56 676 640 467 • 31 Longview CT, Thomastown, VIC 3074, Australia
Same-day dispatch • Australian stock • FDA-BAM compliance documentation included

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