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Polymyxin B sulfate research-grade powder for microbiological laboratory use
  • Polymyxin B sulfate research-grade powder for microbiological laboratory use
  • Polymyxin B sulfate research-grade powder for microbiological laboratory use
Polymyxin B Sulfate

Polymyxin B Sulfate

$79.00
Weight

Polymyxin B Sulfate Powder

Research-Grade Polypeptide Antibiotic
Catalog Number: AS-2034

Product Information

  • Catalog Number: AS-2034

  • CAS Number: 1405-20-5

  • Molecular Formula: C₅₆H₉₈N₁₆O₁₃ · H₂SO₄

  • Molecular Weight: 1301.56 g/mol

  • Form: Powder

Overview

Polymyxin B Sulfate is a polypeptide antibiotic used in microbiological and biochemical research for its strong activity against Gram-negative bacteria. Its antibacterial action is based on disruption of the bacterial cell membrane, resulting in loss of membrane integrity and leakage of intracellular contents.

The compound shows activity primarily against Gram-negative organisms, including non-fermentative bacteria and members of the Enterobacteriaceae family. It is inactive against Gram-positive bacteria and anaerobes, as their cell wall structures prevent effective interaction with the cytoplasmic membrane.

In laboratory settings, Polymyxin B Sulfate is commonly employed as a selective agent, reference antibiotic, or tool for studying membrane structure, permeability, and resistance mechanisms.

Applications

  • Microbiological research and method development

  • Selective inhibition of Gram-negative bacteria in culture media

  • Studies of bacterial outer membrane structure and permeability

  • Antimicrobial susceptibility and resistance research

  • Investigation of lipopolysaccharide (LPS) interactions

Mechanism of Action

Polymyxin B binds to lipopolysaccharides (LPS) and phospholipids in the outer membrane of Gram-negative bacteria. This interaction disrupts membrane integrity, increases permeability, and causes leakage of essential intracellular components, leading to bacterial cell death under susceptible conditions.

Key Features & Benefits

  • Strong activity against Gram-negative bacteria

  • Ineffective against Gram-positive bacteria and anaerobes, enabling selective use

  • Useful tool for membrane-targeting antibiotic studies

  • Supplied with consistent quality for reproducible laboratory results

Storage & Stability

  • Store in a cool, dry place

  • Protect from moisture and light

  • Keep container tightly closed when not in use

Intended Use

For laboratory research use only.
Not for human or animal use.

Quality & Compliance

  • Supplied for research and laboratory applications

  • Manufactured and handled under controlled conditions

  • SDS and COA available upon request

Customs & Trade Information

HS / AHECC Code: 2941.90.00
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