Praziquantel
Praziquantel
Research-Grade Anti-Helmintic Compound & TRPM8 Channel Agonist
Product Identification
Chemical & Physical Information
Product Name: Praziquantel
Catalogue Number: AC-2053
CAS Number: 55268-74-1
Molecular Formula: C₁₉H₂₄N₂O₂
Molecular Weight: 312.41 g/mol
Purity: ≥ 99 %
Form: White to off-white crystalline powder
Product Description
Praziquantel is a high-purity synthetic anti-helminthic compound widely used in parasitology, pharmacology, and ion-channel research. It is particularly studied for its activity against parasitic flatworms, including trematodes (flukes) and cestodes (tapeworms).
At the cellular level, praziquantel increases parasite membrane permeability to calcium ions, resulting in sustained muscle contraction, paralysis, and loss of attachment. In mammalian systems, it is also recognised as an agonist of the TRPM8 (Transient Receptor Potential Melastatin 8) ion channel, making it relevant for neuroscience and ion-channel mechanism studies.
Ausamics Praziquantel is supplied as a research-grade crystalline powder with high chemical purity, suitable for controlled laboratory investigations and reproducible experimental outcomes.
Mechanism of Action
Functional Activity
Induces calcium ion influx in parasitic flatworm membranes
Causes spastic paralysis and detachment of parasites
Acts as a TRPM8 ion channel agonist in mammalian research models
Typical Characteristics
Physicochemical Properties
Appearance: White to off-white crystalline powder
Solubility: Soluble in organic solvents; limited aqueous solubility
Stability: Stable under recommended storage conditions
Typical Applications
Parasitology Research
Studies of trematode and cestode biology
Evaluation of antiparasitic mechanisms
Pharmacology & Drug Development
Mechanistic studies of ion-channel modulation
Pharmacokinetics and resistance research
Veterinary & Biomedical Research
Non-clinical antiparasitic compound screening
Comparative drug-action studies
Key Features
Product Advantages
High-purity (≥ 99 %) research-grade material
Well-characterised mechanism of action
Suitable for parasitology, ion-channel, and pharmacological studies
Consistent batch-to-batch quality
Certificate of Analysis (COA) available on request
Storage & Stability
Storage Conditions
Store at ≤ –15 °C
Keep container tightly sealed
Protect from light and moisture
Stable when stored under recommended conditions
Intended Use
Regulatory Statement
For laboratory research use only.
Not intended for human or veterinary therapeutic use.
Not a medicinal or therapeutic good.
Quality & Supply Assurance
Manufacturing & Documentation
Manufactured under controlled conditions
Supplied with batch-specific Certificate of Analysis (COA)
Safety Data Sheet (SDS) available
Technical support provided by Ausamics Life Science
Customs & Trade Information
Classification
HS / AHECC Code: 2933.99.90
Heterocyclic compounds with nitrogen hetero-atoms