ASC-8018
Mannitol Powder – Food Grade Sweetener (E421) | Low-Calorie Sugar Substitute
Mannitol Powder — ASC-8018
High-Purity Food-Grade Sweetener, Pharmaceutical Excipient & Functional Ingredient. Low hygroscopicity, mild sweetness, and exceptional formulation stability. Same-week dispatch from Melbourne.
Overview
Mannitol Powder is a high-purity polyol (sugar alcohol) widely used as a food-grade sweetener, pharmaceutical excipient, and functional ingredient across food, nutraceutical, cosmetic, and industrial applications. It is supplied as a white crystalline powder and valued for its low hygroscopicity, chemical stability, pleasant cooling sensation, and mild sweetness, making it particularly suitable for moisture-sensitive formulations.
AuSaMicS Mannitol Powder (ASC-8018) is manufactured under stringent quality controls to deliver consistent purity, particle quality, and performance across both small-scale artisan formulation and large-scale industrial production. Its versatility across multiple regulated sectors — food (E421), pharmaceutical excipient, nutraceutical, and cosmetic — makes it one of the most flexible polyols available.
Key Features & Benefits
- High-purity, food-grade quality (E421)
- Low hygroscopicity — improved product shelf life
- Mild sweetness with a clean, cool taste
- Pleasant cooling sensation in oral applications
- Low glycaemic index — suitable for diabetic-friendly formulations
- Non-cariogenic — does not contribute to dental decay
- Heat-stable for cooking and baking applications
- Excellent compatibility with actives and excipients
- Suitable for direct compression in tablet manufacture
- Multiple pack sizes for artisan to industrial scale
Chemical & Physical Properties
| Chemical Name | D-Mannitol (D-(-)-Mannitol) |
| Synonyms | Manna Sugar, Mannite, D-Mannite, E421, Osmitrol, Mannidex, Resectisol |
| CAS Number | 69-65-8 |
| Molecular Formula | C₆H₁₄O₆ |
| Molecular Weight | 182.17 g/mol |
| E Number | E421 (food additive — bulk sweetener / humectant) |
| Appearance | White crystalline powder |
| Odour | Odourless |
| Taste | Mild sweetness (~50–60% of sucrose); cooling sensation |
| Solubility in Water | ~182 g/L at 25°C; ~670 g/L at 90°C |
| Solubility in Ethanol | Slightly soluble |
| Melting Point | 165–169°C |
| Optical Rotation [α]D²⁰ | +23° to +24° (c = 10, in water) |
| Hygroscopicity | Very low — stable under ambient humidity |
| Caloric Value | ~1.6 kcal/g (EU); ~1.6–2.4 kcal/g (US FDA) |
| Glycaemic Index | ≤2 (negligible) |
| Catalogue Number | ASC-8018 |
| Grade | Food Grade / Pharmaceutical Excipient Grade |
Biochemistry & Mode of Action
Ingredients & Composition
| Component | Purity / Content | Function | Mechanism / Notes |
|---|---|---|---|
| D-Mannitol | ≥98.0% (food grade); ≥99.0% (pharma grade) | Primary active — sweetener, bulking agent, excipient | Polyol providing low-caloric sweetness, low hygroscopicity, and non-reactive filler properties. Endothermic dissolution produces cooling sensation. |
Comparative Polyol / Sweetener Analysis
| Sweetener | Type | Sweetness (vs Sucrose) | GI | Hygroscopic | kcal/g | Key Use |
|---|---|---|---|---|---|---|
| Mannitol (ASC-8018) | Polyol | ~50–60% | ≤2 | Very low ✓ | ~1.6 | Excipient, sugar-free confectionery, pharma filler |
| Glycine (BA-1001) | Amino acid | ~70% | Low | Moderate | ~4 | Sweetener / flavour enhancer in food & pharma |
| Sorbitol | Polyol | ~50–70% | 9 | High ✗ | 2.6 | Humectant, sweetener — hygroscopic limitation |
| Xylitol | Polyol | ~100% | 7–13 | Moderate | 2.4 | Sugar-free confectionery, dental care products |
| Erythritol | Polyol | ~60–80% | 0 | Very low | ~0.2 | Zero-calorie sweetener; baking and beverages |
| Dextrose Monohydrate (ASF-3002) | Monosaccharide | ~70–80% | 100 | Moderate | 3.75 | Fermentation, baking, sports nutrition |
| Sucrose | Disaccharide | 100% (reference) | 65 | Moderate | 4 | Standard reference sweetener |
| Maltodextrin DE17 (Benario) | Polysaccharide | ~15–20% | 85–110 | Moderate | ~4 | Bulking agent, carrier, spray-drying aid |
Pros & Cons Analysis
✓ Advantages
- Very low hygroscopicity — ideal for dry and moisture-sensitive formulations
- Low GI — suitable for diabetic-friendly and low-sugar products
- Non-cariogenic — does not feed oral bacteria
- Pleasant cooling taste — excellent mouthfeel in oral dosage forms
- No Maillard browning — colour-stable in heat-processed products
- Suitable for direct compression in pharma tablet manufacture
- Approved in food (E421), pharma (USP/EP/BP), and cosmetic sectors
- Chemically inert — compatible with most actives and excipients
⚠ Considerations
- Lower sweetness (~50–60% of sucrose) — may need blending
- Laxative effect possible at high intake levels (>20 g/day)
- Lower water solubility than sorbitol — may require warm water
- Higher cost than sorbitol or dextrose per unit weight
- EU labelling: products containing mannitol must carry "excessive consumption may have laxative effects" warning above 10% content
- Not suitable as sole humectant — lacks moisture retention of sorbitol
Preparation & Dissolution Guide
- Weigh the required quantity of mannitol powder using a calibrated balance
- For aqueous solutions: add powder to purified or deionised water at room temperature or slightly warmed (40–60°C) and stir until fully dissolved
- For tablet/capsule formulations: blend mannitol directly with active ingredients for direct compression; screen if required for uniform particle size
- For confectionery: incorporate into recipe at the appropriate processing stage; mannitol is heat-stable up to its melting point (~165°C)
- For oral care products: incorporate into the aqueous phase of the formulation with mixing
- Adjust final concentration or blend ratio to achieve desired sweetness, texture, or bulking effect
Usage Considerations
EU Labelling Requirement: Food products containing more than 10% added polyols must carry the statement: "excessive consumption may produce laxative effects."
Pharmaceutical Use: Complies with USP, EP, BP, and JP monographs for Mannitol (excipient grade). Suitable for parenteral, oral solid dosage, and lyophilisation applications at appropriate specification levels.
Storage & Stability
Quality & Documentation
Related Products
Dextrose Monohydrate (ASF-3002) · Maltodextrin DE17 · Glycine (BA-1001) · L-Glutamine (BA-1006) · Citric Acid Monohydrate · Sodium Citrate Dihydrate · Potassium Citrate Monohydrate · Taurine (BA-1022)
Technical Data Sheet — Mannitol Powder (ASC-8018)
1. Product Identification
| Product Name | Mannitol Powder |
| Catalogue Number | ASC-8018 |
| IUPAC Name | (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol |
| CAS Number | 69-65-8 |
| Molecular Formula | C₆H₁₄O₆ |
| Molecular Weight | 182.17 g/mol |
| E Number | E421 |
| Grade | Food Grade / Pharmaceutical Excipient Compatible |
| Supplier | AuSaMicS Pty Ltd, Thomastown VIC 3074, Australia |
2. Mode of Action & Functional Properties
3. Physical & Chemical Properties
| Appearance | White crystalline powder |
| Purity (food grade) | ≥98.0% |
| Purity (pharma-compatible) | ≥99.0% |
| Melting Point | 165–169°C |
| Solubility in Water (25°C) | ~182 g/L |
| Solubility in Water (90°C) | ~670 g/L |
| Optical Rotation [α]D²⁰ | +23° to +24° (10% w/v aqueous) |
| pH (10% aqueous solution) | 5.0–8.0 (neutral) |
| Loss on Drying | ≤0.3% |
| Residue on Ignition | ≤0.1% |
| Hygroscopicity | Very low (<0.3% moisture uptake at 60% RH) |
| Bulk Density | ~400–600 g/L (varies with particle size grade) |
| Heat of Solution | ~−120 J/g (endothermic — cooling sensation) |
| Reducing Sugars | ≤0.1% (non-reducing) |
4. Quality Control Specifications
| Test Parameter | Method | Specification | Notes |
|---|---|---|---|
| Appearance | Visual | White crystalline powder, free-flowing | — |
| Assay (D-Mannitol) | GC or HPLC | ≥98.0% (food); ≥99.0% (pharma) | Dry basis |
| Loss on Drying (105°C, 3h) | Gravimetric | ≤0.3% | USP/EP/BP compliant specification |
| Residue on Ignition | Gravimetric (600°C) | ≤0.1% | — |
| pH (10% aqueous solution) | Potentiometry | 5.0–8.0 | Neutral to slightly acidic |
| Optical Rotation [α]D²⁰ | Polarimetry | +23.0° to +24.0° | 10% w/v aqueous; confirms D-isomer |
| Reducing Sugars | Fehling / HPLC | ≤0.1% | Non-reducing — confirms no glucose/fructose contamination |
| Heavy Metals (as Pb) | ICP-MS | ≤10 ppm | — |
| Arsenic (as As) | ICP-MS | ≤1 ppm | — |
| Chloride | Titration | ≤50 ppm | — |
| Sulphate | Gravimetric/turbidimetric | ≤100 ppm | — |
| Microbial Count (TPC) | Plate count | ≤1000 CFU/g | Food grade specification; ≤100 CFU/g for pharma grade |
| E. coli | MPN / membrane filtration | Absent / 10 g | ≤10 CFU per inoculum |
| Salmonella spp. | ISO 6579 | Absent / 25 g | — |
5. Typical Formulation Guidance
| Application | Typical Inclusion Level | Function | Notes |
|---|---|---|---|
| Direct compression tablets | 20–80% w/w | Filler / diluent | Excellent compressibility; pleasant taste for chewable tablets |
| Lyophilisation (freeze-drying) | 1–10% w/v | Cryoprotectant / bulking agent | Forms elegant cake structure; widely used in biopharmaceuticals |
| Sugar-free confectionery | 20–60% w/w | Bulk sweetener / anti-caking | Blend with high-intensity sweetener to compensate lower sweetness |
| Chewing gum | 10–30% w/w | Cooling agent / sweetener | Provides freshness sensation |
| Toothpaste / oral care | 5–30% w/w | Humectant / sweetener | Non-cariogenic; cooling effect |
| Powdered beverage mixes | 5–20% w/w | Bulking / anti-caking agent | Low hygroscopicity prevents caking |
6. Storage & Stability
Shelf life: ≥3 years from manufacture date under recommended conditions.
Stability notes: Mannitol is chemically stable, non-hygroscopic under ambient conditions, and does not undergo significant degradation during standard food-processing or pharmaceutical manufacturing operations. Stable to autoclaving (121°C, 15 min) when in solution at appropriate concentration.
7. Literature / References
- Rowe RC, Sheskey PJ, Cook WG, Fenton ME (Eds.) (2012). Handbook of Pharmaceutical Excipients, 7th ed. Pharmaceutical Press. Entry: Mannitol, pp. 424–430.
- United States Pharmacopeia (USP). Mannitol Monograph. USP–NF, current edition.
- European Pharmacopoeia (EP). Mannitol Monograph. Ph. Eur. 10th edition.
- Food Standards Australia New Zealand (FSANZ). Food Additive E421 — Mannitol. FSANZ Food Standards Code, Schedule 15.
- European Parliament & Council Regulation (EC) No 1333/2008 on food additives. Annex II: Mannitol (E421).
Safety Data Sheet — Mannitol Powder (ASC-8018)
Prepared in accordance with the Australian Code for the Labelling of Workplace Hazardous Chemicals and GHS. Revision date: 2025.
Section 1 — Identification
| Product Name | Mannitol Powder |
| Catalogue Number | ASC-8018 |
| CAS Number | 69-65-8 |
| Supplier | AuSaMicS Pty Ltd | 31 Longview CT, Thomastown VIC 3074 | +61 412 520 598 | support@ausamics.com |
| Recommended Use | Food sweetener / pharmaceutical excipient / cosmetic ingredient / industrial formulation |
Section 2 — Hazard Identification
Note: Combustible dust hazard may exist when fine powder is suspended in air at sufficient concentration — standard good housekeeping applies.
Section 3 — Composition
| Component | CAS | Formula | Content |
|---|---|---|---|
| D-Mannitol | 69-65-8 | C₆H₁₄O₆ | ≥98.0% |
Section 4 — First Aid Measures
| Inhalation | Remove to fresh air. Mannitol is a food substance — no acute toxicity expected. Seek medical attention if symptoms persist. |
| Skin Contact | Wash with soap and water. No irritation expected at food-grade concentrations. |
| Eye Contact | Rinse with water for 15 minutes. Seek medical advice if irritation persists. |
| Ingestion | Food-approved substance. Excessive ingestion may cause laxative effects. Seek medical advice if symptomatic. |
Section 5 — Fire-Fighting Measures
| Flammability | Not readily flammable; combustible solid above ~460°C |
| Extinguishing Media | CO₂, dry powder, foam, water spray |
| Special Hazards | Fine dust may form explosive mixture — prevent dust accumulation in enclosed spaces |
Section 6 — Accidental Release
Sweep or vacuum up carefully to minimise dust. Avoid generating airborne dust. Dispose in accordance with local regulations or reclaim for intended use if uncontaminated.
Section 7 — Handling & Storage
| Handling | Handle in well-ventilated areas. Minimise dust generation. Standard food-handling hygiene applies. |
| Storage | 15–25°C, tightly sealed, away from moisture and contamination. Keep away from strong oxidising agents. |
Section 8 — Exposure Controls / PPE
| Exposure Limits | No specific OEL established. Treat as nuisance dust: TWA 10 mg/m³ (inhalable), 3 mg/m³ (respirable) |
| Respiratory | Dust mask (P1) if dust generation expected |
| Hands | Standard food-handling gloves; nitrile recommended for extended contact |
| Eyes | Safety glasses during powder handling |
Section 9 — Physical & Chemical Properties
| Appearance | White crystalline powder |
| Odour | Odourless |
| Melting Point | 165–169°C |
| Solubility | ~182 g/L in water at 25°C |
| pH (10% aq.) | 5.0–8.0 |
Section 10 — Stability & Reactivity
| Stability | Stable under normal conditions |
| Conditions to Avoid | Prolonged exposure to high humidity, strong oxidisers |
| Incompatible Materials | Strong oxidising agents |
| Decomposition Products | CO₂, CO, water vapour at elevated temperature |
Section 11 — Toxicological Information
| Acute Oral Toxicity (rat) | LD₅₀ >13,000 mg/kg (very low toxicity; food substance) |
| Skin / Eye Irritation | Non-irritating |
| Carcinogenicity | Not classified (IARC, NTP, OSHA) |
| Reproductive Toxicity | Not classified |
| Laxative Effect | Possible at high dietary intake (>20 g/day in adults) due to osmotic effect in large intestine |
Sections 12–16 — Environmental, Disposal, Transport, Regulatory, Other
| Ecological Information | Not classified as environmentally hazardous. Readily biodegradable. |
| Disposal | Dispose in accordance with local regulations. May be reclaimed for intended food/industrial use if uncontaminated. |
| Transport | Not classified as dangerous goods (ADG, IATA, IMDG) |
| Regulatory | Listed on AIIC. Permitted food additive (FSANZ E421). Pharmacopoeial monographs: USP, EP, BP, JP. |
| SDS Prepared by | AuSaMicS Pty Ltd — Revision 2025. Contact: support@ausamics.com |
Certificate of Analysis — Mannitol Powder (ASC-8018)
Representative COA. Lot-specific COA available upon request via support@ausamics.com.
| Product Name | Mannitol Powder |
| Catalogue Number | ASC-8018 |
| CAS Number | 69-65-8 |
| E Number | E421 |
| Lot Number | Available on product label |
| Manufacture Date | Available on product label |
| Expiry Date | Available on product label |
| Supplied by | AuSaMicS Pty Ltd, 31 Longview CT, Thomastown VIC 3074, Australia |
Test Results
| Test | Specification | Result | Status |
|---|---|---|---|
| Appearance | White crystalline powder | White crystalline powder, free-flowing | ✓ PASS |
| Assay (D-Mannitol) | ≥98.0% | ≥99.2% | ✓ PASS |
| Loss on Drying | ≤0.3% | ≤0.15% | ✓ PASS |
| Residue on Ignition | ≤0.1% | ≤0.05% | ✓ PASS |
| pH (10% aqueous) | 5.0–8.0 | ~6.2 | ✓ PASS |
| Optical Rotation [α]D²⁰ | +23.0° to +24.0° | +23.5° | ✓ PASS |
| Reducing Sugars | ≤0.1% | <0.05% | ✓ PASS |
| Heavy Metals (as Pb) | ≤10 ppm | <2 ppm | ✓ PASS |
| Arsenic (as As) | ≤1 ppm | <0.1 ppm | ✓ PASS |
| Chloride | ≤50 ppm | <20 ppm | ✓ PASS |
| Sulphate | ≤100 ppm | <40 ppm | ✓ PASS |
| TPC (Microbial) | ≤1000 CFU/g | <100 CFU/g | ✓ PASS |
| E. coli | Absent / 10 g | Not detected | ✓ PASS |
| Salmonella spp. | Absent / 25 g | Not detected | ✓ PASS |
Applications — Mannitol Powder (ASC-8018)
🍬 Food & Confectionery
- Sugar-free and reduced-sugar confectionery
- Chewing gum — cooling and sweetening agent
- Hard and soft candy (sucrose replacement)
- Chocolate coatings in diabetic-friendly ranges
- Anti-caking agent in powdered formulations
🥤 Beverages & Powders
- Powdered drink mixes — anti-caking, low-hygroscopic carrier
- Sports and nutrition powders
- Electrolyte and hydration formulations
- Instant beverage sachets
💊 Pharmaceutical Excipient
- Direct compression tablet filler/diluent
- Chewable tablet base — excellent mouthfeel
- Orally disintegrating tablets (ODT)
- Lyophilisation bulking agent and cryoprotectant
- Capsule filler — inert, non-hygroscopic
🧴 Nutraceutical & Supplements
- Tablet and capsule bulking agent
- Carrier for vitamins and minerals
- Flavour carrier in chewable vitamins
- Low-GI formulations for diabetic-friendly supplements
🪥 Oral Care & Cosmetics
- Toothpaste — sweetener, mild abrasive, cooling agent
- Mouthwash and oral rinse formulations
- Cosmetic creams and lotion formulations
- Skin-feel modifier in topical products
🔬 Laboratory & Industrial
- General laboratory reagent
- Osmotic agent in cell biology experiments
- Buffer and media preparation
- Technical formulation ingredient
Application-Specific Guidance
| Application | Inclusion Level | Key Benefit | Notes |
|---|---|---|---|
| Direct compression tablets | 20–80% | Inert filler, free-flowing | Suitable for moisture-sensitive APIs |
| Freeze-drying (lyophilisation) | 1–10% w/v | Elegant cake; cryoprotection | Standard bulking agent for biopharmaceuticals |
| Sugar-free confectionery | 30–60% | Bulk sweetener, anti-caking | Blend with stevia or sucralose for full sweetness |
| Chewing gum | 10–30% | Cooling sensation, sweetness | Combine with xylitol for enhanced dental benefit |
| Powdered nutrition | 5–20% | Anti-caking, bulk carrier | Low hygroscopicity prevents clumping |
| Toothpaste | 5–30% | Non-cariogenic sweetener, cooling | Compatible with fluoride systems |
Related Products
Dextrose Monohydrate (ASF-3002) · Maltodextrin DE17 · Glycine (BA-1001) · Taurine (BA-1022) · Creatine Monohydrate (BA-1023) · Citric Acid Monohydrate
Cross-Reference / Equivalent Products
The following are equivalent or comparable Mannitol products from major international suppliers. AuSaMicS ASC-8018 is the Australian-stocked alternative — same food-grade and excipient-compatible specification, local availability, same-week Melbourne dispatch.
| Supplier | Product Name | Catalogue Number | Grade / Notes |
|---|---|---|---|
| AuSaMicS 🇦🇺 | Mannitol Powder | ASC-8018 | Food grade / excipient compatible — Australian stock, same-week dispatch, COA included |
| Sigma-Aldrich / Merck | D-Mannitol | M4125, M9647, 63559 | Various grades: ReagentPlus, BioReagent, USP grade |
| Thermo Fisher Scientific | D-Mannitol | A16006, BP683 | ACS grade and USP grade options |
| Roquette | PEARLITOL® (Mannitol) | PEARLITOL 100 SD, 200 SD, 300 DC | Spray-dried grades specifically designed for direct compression and ODT |
| SPI Pharma (IFF) | Mannogem™ EZ | Mannogem EZ, Mannogem XL | Pharmaceutical-grade mannitol for direct compression |
| Cargill | Mannitol (food grade) | Proprietary | Food and nutrition grade, commercial volumes |
| Univar Solutions (AU) | D-Mannitol | Various | Distributor — food and pharma grades in Australia |
| TCI Chemicals | D-Mannitol | M0055 | Research grade, ≥98% |
| AppliChem / ITW Reagents | D-Mannitol | A1577 | Biochemistry grade |
Why Choose AuSaMicS?
- Australian stock — no import lead times
- Same-week dispatch from Melbourne
- COA included with every batch
- Competitive pricing for small to large quantities
- Full documentation: COA, SDS, TDS available
- Multiple pack sizes: 100 g to 1 kg
- Direct technical support from Australian supplier
- Food grade and excipient-compatible specification
Intent-Based Search Queries
This product is relevant for the following common search queries:
buy mannitol powder Australia · D-mannitol food grade · mannitol sweetener sugar-free · E421 food additive Australia · mannitol excipient tablets · mannitol direct compression · mannitol same week dispatch Melbourne · ASC-8018 AuSaMicS · mannitol anti-caking agent · low glycaemic sweetener Australia · mannitol pharmaceutical grade Australia · mannitol lyophilisation bulking agent · mannitol oral care ingredient · sugar alcohol sweetener Australia · mannitol sigma equivalent Australia · mannitol food additive bulk · non-hygroscopic sweetener powder Australia · mannitol chewable tablet filler